ethyl 4-(4-(bis(1-methyl-1H-indol-3-yl)methyl)phenoxy)butanoate

Base Information

• Chemical Name: ethyl 4-(4-(bis(1-methyl-1H-indol-3-yl)methyl)phenoxy)butanoate
• CAS No.: 1361044-06-5
• Molecular Formula: C₃₁H₃₂N₂O₃
• Molecular Weight: 480.607
• Mol file: 1361044-06-5.mol

Synonyms:ethyl 4-(4-(bis(1-methyl-1H-indol-3-yl)methyl)phenoxy)butanoate

Chemical Property of ethyl 4-(4-(bis(1-methyl-1H-indol-3-yl)methyl)phenoxy)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-(4-(bis(1-methyl-1H-indol-3-yl)methyl)phenoxy)butanoate

There total 6 articles about ethyl 4-(4-(bis(1-methyl-1H-indol-3-yl)methyl)phenoxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Ethyl 4-bromobutyrate (2969-81-5) + 1,1-dimethyl-1,1-bis(3’-indolyl)-1-(p-hydroxyphenyl)methane → ethyl 4-(4-(bis(1-methyl-1H-indol-3-yl)methyl)phenoxy)butanoate (1361044-06-5)

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux;

DOI:10.1039/c5ob00025d

Reference yield: 91.0%

1-methylindole (603-76-9) + ethyl 4-(4-formylphenoxy)butyrate (92991-64-5) → ethyl 4-(4-(bis(1-methyl-1H-indol-3-yl)methyl)phenoxy)butanoate (1361044-06-5)

Guidance literature:

With iodine; In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1021/jm201697v

Reference yield:

1-methylindole (603-76-9) + p-hydroxyphenylglycine (6324-01-2) → ethyl 4-(4-(bis(1-methyl-1H-indol-3-yl)methyl)phenoxy)butanoate (1361044-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: alloxan monohydrate; phosphotungstic acid 44-hydrate / N,N-dimethyl-formamide / 110 °C

2: potassium carbonate / acetonitrile / Reflux

With phosphotungstic acid 44-hydrate; potassium carbonate; alloxan monohydrate; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1039/c5ob00025d

upstream raw materials:

indole

1-methylindole

ethyl 4-(4-formylphenoxy)butyrate

Ethyl 4-bromobutyrate