2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylethynyl]-benzaldehyde

Base Information

• Chemical Name: 2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylethynyl]-benzaldehyde
• CAS No.: 261720-09-6
• Molecular Formula: C₂₂H₂₆O₂Si
• Molecular Weight: 350.533

Synonyms:2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylethynyl]-benzaldehyde

Chemical Property of 2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylethynyl]-benzaldehyde

Chemical Property:

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Technology Process of 2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylethynyl]-benzaldehyde

There total 3 articles about 2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylethynyl]-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethynylbenzyl alcohol (10602-08-1) → 2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylethynyl]-benzaldehyde (261720-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Pd(PPh₃)4; CuI / triethylamine / 20 °C

2: imidazole / CH₂Cl₂

With 1H-imidazole; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; triethylamine; 1: Arylation / 2: Etherification;

DOI:10.1016/S0040-4039(99)02062-6

Reference yield:

ortho-bromobenzaldehyde (6630-33-7) → 2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylethynyl]-benzaldehyde (261720-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Pd(PPh₃)4; CuI / triethylamine / 20 °C

2: imidazole / CH₂Cl₂

With 1H-imidazole; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; triethylamine; 1: Arylation / 2: Etherification;

DOI:10.1016/S0040-4039(99)02062-6

Reference yield:

2-<2-<2-(Hydroxymethyl)phenyl>ethynyl>benzaldehyde (18887-53-1) + tert-butyldimethylsilyl chloride (18162-48-6) → 2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylethynyl]-benzaldehyde (261720-09-6)

Guidance literature:

With 1H-imidazole; In dichloromethane;

DOI:10.1016/S0040-4039(99)02062-6

upstream raw materials:

2-<2-<2-(Hydroxymethyl)phenyl>ethynyl>benzaldehyde

tert-butyldimethylsilyl chloride

2-ethynylbenzyl alcohol

ortho-bromobenzaldehyde

Downstream raw materials:

(4S,5R)-4,5-Bis-(2-{(Z)-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-vinyl}-phenyl)-[1,3]dioxolane-2-thione

(1S,2R)-1,2-Bis-(2-{(Z)-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-vinyl}-phenyl)-ethane-1,2-diol

C₄₄H₅₆O₂Si₂

C₄₀H₂₆O₂

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