ethyl (E)-<1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene>acetate

Base Information

• Chemical Name: ethyl (E)-<1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene>acetate
• CAS No.: 222541-11-9
• Molecular Formula: C₂₉H₂₈N₂O₄
• Molecular Weight: 468.552

Synonyms:ethyl (E)-<1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene>acetate

Chemical Property of ethyl (E)-<1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene>acetate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl (E)-<1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene>acetate

There total 3 articles about ethyl (E)-<1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ortho-toluoyl chloride (933-88-0) → ethyl (E)-<1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene>acetate (222541-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) sodium hydride / 1.) THF, 0 deg C, 1 h, 2.) THF, RT, 18 h

With sodium hydride; triethylamine; In dichloromethane;

DOI:10.1248/cpb.47.329

Reference yield:

1-(4-aminobenzoyl)-2,3,4,5-tetrahydro1H-1-benzazepin-5-one (137976-09-1) → ethyl (E)-<1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene>acetate (222541-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) sodium hydride / 1.) THF, 0 deg C, 1 h, 2.) THF, RT, 18 h

With sodium hydride; triethylamine; In dichloromethane;

DOI:10.1248/cpb.47.329

Reference yield:

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 2-methyl-4'-[(5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]benzanilide (137976-61-5) → ethyl (E)-<1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene>acetate (222541-11-9)

Guidance literature:

With sodium hydride; Yield given; Multistep reaction; 1.) THF, 0 deg C, 1 h, 2.) THF, RT, 18 h;

DOI:10.1248/cpb.47.329

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

2-methyl-4'-[(5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]benzanilide

ortho-toluoyl chloride

1-(4-aminobenzoyl)-2,3,4,5-tetrahydro1H-1-benzazepin-5-one

Downstream raw materials:

(E)-N-methyl-<1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene>acetamide

ethyl <1-<4-(2-methylbenzoylamino)benzoyl>-2,3-dihydro-1H-1-benzoazepin-5-yl>acetate

ethyl <1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-yl>acetate

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