Pyrazolo[1,5-a]pyridine-2-carboxylic acid, 4,5,6,7-tetrahydro- (9CI)

Base Information

• Chemical Name: Pyrazolo[1,5-a]pyridine-2-carboxylic acid, 4,5,6,7-tetrahydro- (9CI)
• CAS No.: 307313-03-7
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2933990090
• Mol file: 307313-03-7.mol

Synonyms:4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid;

Chemical Property of Pyrazolo[1,5-a]pyridine-2-carboxylic acid, 4,5,6,7-tetrahydro- (9CI)

Chemical Property:

• Boiling Point: 397.082 °C at 760 mmHg
• PKA: 4.12±0.20(Predicted)
• Flash Point: 193.949 °C
• PSA: 55.12000
• Density: 1.454 g/cm³
• LogP: 0.91760
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazolo[1,5-a]pyridine-2-carboxylic acid, 4,5,6,7-tetrahydro- (9CI)

There total 9 articles about Pyrazolo[1,5-a]pyridine-2-carboxylic acid, 4,5,6,7-tetrahydro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

pyrazolo[1,5-a]pyridine-2-carboxylic acid (63237-88-7) → 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid (307313-03-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 80 ℃; for 4h; under 12001.2 Torr;

Reference yield: 84.8%

4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid ethyl ester (307307-84-2) → 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid (307313-03-7)

Guidance literature:

With water; sodium hydroxide; at 0 - 20 ℃; for 3.5h;

Reference yield: 78.0%

methyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylate (307307-82-0) → 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid (307313-03-7)

Guidance literature:

With methanol; potassium hydroxide; at 20 ℃;

DOI:10.1016/j.bmcl.2013.06.044

upstream raw materials:

4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid ethyl ester

pyrazolo[1,5-a]pyridine-2-carboxylic acid

4,5,6,7-tetrahydro<1.2.3>oxadiazolo<3,4-a>pyridin-3-one

pipecolic Acid

Downstream raw materials:

4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-2-carboxylic acid chloride

C₂₀H₂₄F₂N₄O

(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-2-yl)methanol