Ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylate

Base Information

• Chemical Name: Ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylate
• CAS No.: 307307-84-2
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.233
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40474347
• Wikidata: Q82304319
• Mol file: 307307-84-2.mol

Synonyms:307307-84-2;Ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylate;4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyridine-2-carboxylic acid ethyl ester;MFCD11975790;ethyl 4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-2-carboxylate;Pyrazolo[1,5-a]pyridine-2-carboxylic acid, 4,5,6,7-tetrahydro-, ethyl ester;A5617;SCHEMBL2928372;DTXSID40474347;RLYRMESNENRMHE-UHFFFAOYSA-N;ethyl4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylate;AKOS015854245;SB36501;AS-36214;SY205073;BB 0261508;CS-0215400;FT-0682456;EN300-244259;4-ethyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylate;4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid ethyl ester;4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic Acid Ethylester

Chemical Property of Ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylate

Chemical Property:

• Boiling Point: 343.68 °C at 760 mmHg
• PKA: 0.49±0.20(Predicted)
• Flash Point: 161.652 °C
• PSA: 44.12000
• Density: 1.254 g/cm³
• LogP: 1.39610
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 194.105527694
• Heavy Atom Count: 14
• Complexity: 220

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=NN2CCCCC2=C1

Technology Process of Ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylate

There total 9 articles about Ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4,5,6,7-tetrahydro<1.2.3>oxadiazolo<3,4-a>pyridin-3-one (105786-95-6) + propynoic acid ethyl ester (623-47-2) → 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid ethyl ester (307307-84-2) + 4,5,6,7-Tetrahydropyrazolo<1,5-a>pyridin-3-carbonsaeureethylester (118055-06-4)

Guidance literature:

In o-xylene; for 16h; Heating;

DOI:10.1021/jm060021p

Reference yield: 65.0%

tetrahydropyridino[1,2-c][1,2,3]oxadiazolone (121193-65-5) + propynoic acid ethyl ester (623-47-2) → 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid ethyl ester (307307-84-2)

Guidance literature:

In o-xylene; for 16h; Heating / reflux;

Reference yield: 56.0%

4,5,6,7-tetrahydro<1.2.3>oxadiazolo<3,4-a>pyridin-3-one (105786-95-6) + propynoic acid ethyl ester (623-47-2) → 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid ethyl ester (307307-84-2)

Guidance literature:

In xylene; for 6h; Reflux;

upstream raw materials:

4,5,6,7-tetrahydro<1.2.3>oxadiazolo<3,4-a>pyridin-3-one

propynoic acid ethyl ester

1-nitroso-piperidine-2-carboxylic acid

pipecolic Acid

Downstream raw materials:

(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-2-yl)methanol

4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carbaldehyde

6-[acetoxy-(4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyridin-2-yl)-methyl]-6-bromo-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid