<1-(1,1-dimethylethoxycarbonyl)-2-pyrrolyl>methyl 4-phenyl-3(E)-butenoate

Base Information

• Chemical Name: <1-(1,1-dimethylethoxycarbonyl)-2-pyrrolyl>methyl 4-phenyl-3(E)-butenoate
• CAS No.: 175689-39-1
• Molecular Formula: C₂₀H₂₃NO₄
• Molecular Weight: 341.407
• Mol file: 175689-39-1.mol

Synonyms:<1-(1,1-dimethylethoxycarbonyl)-2-pyrrolyl>methyl 4-phenyl-3(E)-butenoate

Chemical Property of <1-(1,1-dimethylethoxycarbonyl)-2-pyrrolyl>methyl 4-phenyl-3(E)-butenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <1-(1,1-dimethylethoxycarbonyl)-2-pyrrolyl>methyl 4-phenyl-3(E)-butenoate

There total 4 articles about <1-(1,1-dimethylethoxycarbonyl)-2-pyrrolyl>methyl 4-phenyl-3(E)-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

β-benzalpropionic acid chloride (60773-92-4) + tert-butyl 2-(hydroxymethyl)-1H-pyrrole-1-carboxylate (175689-33-5) → <1-(1,1-dimethylethoxycarbonyl)-2-pyrrolyl>methyl 4-phenyl-3(E)-butenoate (175689-39-1)

Guidance literature:

With pyridine; In dichloromethane; Ambient temperature; overnight;

DOI:10.1021/jo952127q

Reference yield:

2-pyrrole aldehyde (1003-29-8,254729-95-8) → <1-(1,1-dimethylethoxycarbonyl)-2-pyrrolyl>methyl 4-phenyl-3(E)-butenoate (175689-39-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / acetonitrile / 24 h / 25 °C

2: 90 percent / NaBH₄ / methanol / 1 h / 0 °C

3: 68 percent / pyridine / CH₂Cl₂ / Ambient temperature; overnight

With pyridine; sodium tetrahydroborate; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/jo952127q

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → <1-(1,1-dimethylethoxycarbonyl)-2-pyrrolyl>methyl 4-phenyl-3(E)-butenoate (175689-39-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / acetonitrile / 24 h / 25 °C

2: 90 percent / NaBH₄ / methanol / 1 h / 0 °C

3: 68 percent / pyridine / CH₂Cl₂ / Ambient temperature; overnight

With pyridine; sodium tetrahydroborate; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/jo952127q

upstream raw materials:

β-benzalpropionic acid chloride

tert-butyl 2-(hydroxymethyl)-1H-pyrrole-1-carboxylate

2-pyrrole aldehyde

di-tert-butyl dicarbonate

Downstream raw materials:

<1-(1,1-dimethylethoxycarbonyl)-2-pyrrolyl>methyl 2-diazo-4-phenyl-3(E)-butenoate