Pyrazolo[1,5-a]pyridine-3-carboxaldehyde, 4,5,6,7-tetrahydro- (9CI)

Base Information

• Chemical Name: Pyrazolo[1,5-a]pyridine-3-carboxaldehyde, 4,5,6,7-tetrahydro- (9CI)
• CAS No.: 307308-03-8
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Hs Code.: 2933990090
• Mol file: 307308-03-8.mol

Synonyms:4,5,6,7-Tetrahydro-pyrazolo[1,5-a]pyridine-3-carboxaldehyde

Chemical Property of Pyrazolo[1,5-a]pyridine-3-carboxaldehyde, 4,5,6,7-tetrahydro- (9CI)

Chemical Property:

• PSA: 34.89000
• LogP: 1.03190
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridine-3-carbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazolo[1,5-a]pyridine-3-carboxaldehyde, 4,5,6,7-tetrahydro- (9CI)

There total 3 articles about Pyrazolo[1,5-a]pyridine-3-carboxaldehyde, 4,5,6,7-tetrahydro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-pyrazolo<1,5-a>pyridineacarboxaldehyde (73957-66-1) → 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carbaldehyde (307308-03-8)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 - 60 ℃; Inert atmosphere;

Reference yield:

Pyrazolo<1,5-a>pyridin-3-carbonsaeureethylester (16205-44-0) → 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carbaldehyde (307308-03-8)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere

3: palladium on activated charcoal; hydrogen / ethanol / 20 - 60 °C / Inert atmosphere

With lithium aluminium tetrahydride; palladium on activated charcoal; hydrogen; Dess-Martin periodane; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

3-(hydroxymethyl)pyrazolo<1,5-a>pyridine (117782-76-0) → 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carbaldehyde (307308-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen / ethanol / 20 - 60 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; Dess-Martin periodane; In ethanol; dichloromethane;

upstream raw materials:

3-pyrazolo<1,5-a>pyridineacarboxaldehyde

Pyrazolo<1,5-a>pyridin-3-carbonsaeureethylester

3-(hydroxymethyl)pyrazolo<1,5-a>pyridine

Refernces