(R)-4-[1-(4-chlorophenyl)-2-nitroethyl]-5-methyl-2-phenyl-2H-pyrazol-3-ol

Base Information

• Chemical Name: (R)-4-[1-(4-chlorophenyl)-2-nitroethyl]-5-methyl-2-phenyl-2H-pyrazol-3-ol
• CAS No.: 1451195-14-4
• Molecular Formula: C₁₈H₁₆ClN₃O₃
• Molecular Weight: 357.796
• Mol file: 1451195-14-4.mol

Synonyms:(R)-4-[1-(4-chlorophenyl)-2-nitroethyl]-5-methyl-2-phenyl-2H-pyrazol-3-ol

Chemical Property of (R)-4-[1-(4-chlorophenyl)-2-nitroethyl]-5-methyl-2-phenyl-2H-pyrazol-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (R)-4-[1-(4-chlorophenyl)-2-nitroethyl]-5-methyl-2-phenyl-2H-pyrazol-3-ol

There total 1 articles about (R)-4-[1-(4-chlorophenyl)-2-nitroethyl]-5-methyl-2-phenyl-2H-pyrazol-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-chloro-4-(2-nitrovinyl)benzene (706-07-0,5153-70-8) + edaravone (89-25-8) → (R)-4-[1-(4-chlorophenyl)-2-nitroethyl]-5-methyl-2-phenyl-2H-pyrazol-3-ol (1451195-14-4)

Guidance literature:

With quinine; In chloroform; at 20 ℃; for 4h; enantioselective reaction;

DOI:10.1039/c3ob41045e

Reference yield: 90.0%

(R)-4-[1-(4-chlorophenyl)-2-nitroethyl]-5-methyl-2-phenyl-2H-pyrazol-3-ol (1451195-14-4) → 4-chloro-4-(1-(4-chlorophenyl)-2-nitroethyl)-3-methyl-1-phenyl-1H-pyrazol-5-one

Guidance literature:

With N-chloro-succinimide; In toluene; at 20 ℃; for 24h; stereoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1007/s11426-013-5017-3

Reference yield:

(R)-4-[1-(4-chlorophenyl)-2-nitroethyl]-5-methyl-2-phenyl-2H-pyrazol-3-ol (1451195-14-4) → 4-(1-(4-chlorophenyl)-2-nitroethyl)-4-fluoro-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (1440199-46-1)

Guidance literature:

With N-fluorobis(benzenesulfon)imide; In toluene; at 20 ℃;

DOI:10.1002/chem.201202636

upstream raw materials:

1-chloro-4-(2-nitrovinyl)benzene

edaravone

Downstream raw materials:

4-(1-(4-chlorophenyl)-2-nitroethyl)-4-fluoro-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one