methyl 4--N-prop-2-ynylamino>-2-nitrobenzoate

Base Information

• Chemical Name: methyl 4--N-prop-2-ynylamino>-2-nitrobenzoate
• CAS No.: 129175-88-8
• Molecular Formula: C₂₁H₁₈N₄O₅
• Molecular Weight: 406.398

Synonyms:methyl 4--N-prop-2-ynylamino>-2-nitrobenzoate

Chemical Property of methyl 4--N-prop-2-ynylamino>-2-nitrobenzoate

Chemical Property:

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Technology Process of methyl 4--N-prop-2-ynylamino>-2-nitrobenzoate

There total 1 articles about methyl 4--N-prop-2-ynylamino>-2-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

methyl 2-nitro-4-(prop-2-ynylamino)benzoate (129175-87-7) + 4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline (112888-43-4) → methyl 4--N-prop-2-ynylamino>-2-nitrobenzoate (129175-88-8)

Guidance literature:

With 2,6-dimethylpyridine; In N,N-dimethyl acetamide; at 80 ℃; for 4h;

DOI:10.1021/jm00173a026

Reference yield: 82.0%

methyl 4--N-prop-2-ynylamino>-2-nitrobenzoate (129175-88-8) → 4--N-prop-2-ynylamino>-2-nitrobenzoic acid (129175-89-9)

Guidance literature:

With sodium hydroxide; In ethanol; for 2h;

DOI:10.1021/jm00173a026

Reference yield: 36.0%

o-amino-p-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino]benzoic acid + iron (7439-89-6) + methyl 4--N-prop-2-ynylamino>-2-nitrobenzoate (129175-88-8) → methyl o-amino-p-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino]benzoate (131052-80-7)

Guidance literature:

With hydrogenchloride; In methanol;

upstream raw materials:

methyl 2-nitro-4-(prop-2-ynylamino)benzoate

4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline

Downstream raw materials:

4--N-prop-2-ynylamino>-2-nitrobenzoic acid

(S)-2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-nitro-benzoylamino}-pentanedioic acid

diethyl N-<4--N-prop-2-ynylamino>-2-nitrobenzoyl>-L-glutamate

methyl o-amino-p-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino]benzoate

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