(E)-1-(pyridin-2-ylmethylene)-4-p-tolylthiosemicarbazide

Base Information

• Chemical Name: (E)-1-(pyridin-2-ylmethylene)-4-p-tolylthiosemicarbazide
• CAS No.: 97213-82-6
• Molecular Formula: C₁₄H₁₄N₄S
• Molecular Weight: 270.358
• Mol file: 97213-82-6.mol

Synonyms:(E)-1-(pyridin-2-ylmethylene)-4-p-tolylthiosemicarbazide

Chemical Property of (E)-1-(pyridin-2-ylmethylene)-4-p-tolylthiosemicarbazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(pyridin-2-ylmethylene)-4-p-tolylthiosemicarbazide

There total 4 articles about (E)-1-(pyridin-2-ylmethylene)-4-p-tolylthiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyridine-2-carbaldehyde (1121-60-4) + 4-(4-methylphenyl)-3-thiosemicarbazide (13278-67-6) → (E)-1-(pyridin-2-ylmethylene)-4-p-tolylthiosemicarbazide (97213-82-6)

Guidance literature:

With ethanol;

Reference yield:

p-toluidine (106-49-0,12221-03-3) → (E)-1-(pyridin-2-ylmethylene)-4-p-tolylthiosemicarbazide (97213-82-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / ethanol; water / 20 °C

1.2: 0.5 h

2.1: hydrazine hydrate; isopropyl alcohol / 0.17 h / Cooling with ice

3.1: pyrrole / ethanol; water / 100 °C

With pyrrole; hydrazine hydrate; triethylamine; isopropyl alcohol; In ethanol; water;

DOI:10.1016/j.bioorg.2020.104576

Reference yield:

1-isothiocyanato-4-methylbenzene (622-59-3) → (E)-1-(pyridin-2-ylmethylene)-4-p-tolylthiosemicarbazide (97213-82-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate; isopropyl alcohol / 0.17 h / Cooling with ice

2: pyrrole / ethanol; water / 100 °C

With pyrrole; hydrazine hydrate; isopropyl alcohol; In ethanol; water;

DOI:10.1016/j.bioorg.2020.104576

upstream raw materials:

pyridine-2-carbaldehyde

4-(4-methylphenyl)-3-thiosemicarbazide

1-isothiocyanato-4-methylbenzene

p-toluidine