2-(cyclopropylamino)-5-methoxybenzenesulfonamide

Base Information

Chemical Name:2-(cyclopropylamino)-5-methoxybenzenesulfonamide
CAS No.:1204575-07-4
Molecular Formula:C₁₀H₁₄N₂O₃S
Molecular Weight:242.299
Hs Code.:

Synonyms:2-(cyclopropylamino)-5-methoxybenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(cyclopropylamino)-5-methoxybenzenesulfonamide

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Technology Process of 2-(cyclopropylamino)-5-methoxybenzenesulfonamide

There total 4 articles about 2-(cyclopropylamino)-5-methoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 5-methoxy-2-((1-methoxycyclopropyl)amino)benzenesulfonamide

: 1204575-07-4
2-(cyclopropylamino)-5-methoxybenzenesulfonamide

Guidance literature:: With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 20 ℃; for 16h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmcl.2019.03.027

Reference yield:

: 27374-25-0
[(1-Ethoxycyclopropyl)oxy]trimethylsilane

: 6451-50-9
2-amino-5-methoxybenzenesulphonamide

: 1204575-07-4
2-(cyclopropylamino)-5-methoxybenzenesulfonamide

Guidance literature:: [(1-Ethoxycyclopropyl)oxy]trimethylsilane; 2-amino-5-methoxybenzenesulphonamide; With acetic acid; In methanol; for 18h; Reflux;

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; for 18h; Reflux;

With hydrogenchloride; In water;

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1204575-07-4
2-(cyclopropylamino)-5-methoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 0.5 h / 0 °C / Inert atmosphere

2: aluminum (III) chloride / 1 h / 100 °C / Inert atmosphere

3: sulfuric acid / water / 3 h / 20 - 140 °C / Inert atmosphere

4: acetic acid / methanol / 18 h / 20 °C / Reflux; Inert atmosphere

5: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 16 h / 20 °C / Reflux; Inert atmosphere

With aluminum (III) chloride; sodium tetrahydroborate; sulfuric acid; boron trifluoride diethyl etherate; acetic acid; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmcl.2019.03.027