1-{3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]phenyl}piperidine-4-carbonitrile

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Chemical Name:1-{3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]phenyl}piperidine-4-carbonitrile
CAS No.:1418295-70-1
Molecular Formula:C₂₆H₂₄F₄N₄O
Molecular Weight:484.496
Hs Code.:

Synonyms:1-{3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]phenyl}piperidine-4-carbonitrile

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Chemical Property of 1-{3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]phenyl}piperidine-4-carbonitrile

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Technology Process of 1-{3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]phenyl}piperidine-4-carbonitrile

There total 11 articles about 1-{3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]phenyl}piperidine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 4395-98-6
4-cyanopiperidine

: 1418295-67-6
1-(3-bromobenzyl)-3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole

: 1418295-70-1
1-{3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]phenyl}piperidine-4-carbonitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In N,N-dimethyl-formamide; at 120 ℃; for 2h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1418295-70-1
1-{3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]phenyl}piperidine-4-carbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

4.1: N,N-dimethyl-formamide / 1 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

6.2: 16 h / -78 - 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 - 5 °C

8.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

9.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Cooling with ice

10.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos / N,N-dimethyl-formamide / 2 h / 120 °C / Microwave irradiation; Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; caesium carbonate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; XPhos; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1418296-88-4
ethyl 5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylate

: 1418295-70-1
1-{3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]phenyl}piperidine-4-carbonitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

3.1: N,N-dimethyl-formamide / 1 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

5.2: 16 h / -78 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 - 5 °C

7.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

8.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Cooling with ice

9.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos / N,N-dimethyl-formamide / 2 h / 120 °C / Microwave irradiation; Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; caesium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; XPhos; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;