(R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(3-nitrobenzenesulfonylamino)hexanoic acid hydroxy amide

Base Information

Chemical Name:(R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(3-nitrobenzenesulfonylamino)hexanoic acid hydroxy amide
CAS No.:1043890-21-6
Molecular Formula:C₂₀H₂₅FN₄O₆S
Molecular Weight:468.506
Hs Code.:

Synonyms:(R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(3-nitrobenzenesulfonylamino)hexanoic acid hydroxy amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(3-nitrobenzenesulfonylamino)hexanoic acid hydroxy amide

Chemical Property:

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Technology Process of (R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(3-nitrobenzenesulfonylamino)hexanoic acid hydroxy amide

There total 5 articles about (R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(3-nitrobenzenesulfonylamino)hexanoic acid hydroxy amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1043890-90-9
(R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(3-nitrobenzenesulfonylamino)hexanoic acid methyl ester

: 1043890-21-6
(R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(3-nitrobenzenesulfonylamino)hexanoic acid hydroxy amide

Guidance literature:: With hydroxylamine; potassium cyanide; In tetrahydrofuran; methanol; water; at 20 ℃; for 16h;

Reference yield:

: 342636-66-2
(4-fluoro-3,5-dimethylphenyl)boronic acid

: 1043890-21-6
(R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(3-nitrobenzenesulfonylamino)hexanoic acid hydroxy amide

Guidance literature:: Multi-step reaction with 4 steps

1: oxygen; copper diacetate; triethylamine / dichloromethane / 87 h / 20 °C / 760.05 Torr / Molecular sieves 4?

2: trifluoroacetic acid / dichloromethane / 19 h / 20 °C

3: triethylamine / dichloromethane / 16 h / 20 °C

4: hydroxylamine; potassium cyanide / tetrahydrofuran; methanol; water / 16 h / 20 °C

With hydroxylamine; oxygen; potassium cyanide; copper diacetate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1043890-88-5
(R)-6-tert-butoxycarbonylamino-2-(4-fluoro-3,5-dimethylphenylamino)hexanoic acid methyl ester

: 1043890-21-6
(R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(3-nitrobenzenesulfonylamino)hexanoic acid hydroxy amide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 19 h / 20 °C

2: triethylamine / dichloromethane / 16 h / 20 °C

3: hydroxylamine; potassium cyanide / tetrahydrofuran; methanol; water / 16 h / 20 °C

With hydroxylamine; potassium cyanide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;