1-{benzyl-[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}-5-[(3-methyl-3H-imidazol-4-ylmrthylene)amino]pentan-3-ol

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Chemical Name:1-{benzyl-[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}-5-[(3-methyl-3H-imidazol-4-ylmrthylene)amino]pentan-3-ol
CAS No.:402921-45-3
Molecular Formula:C₃₁H₃₉N₇O
Molecular Weight:525.697
Hs Code.:

Synonyms:1-{benzyl-[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}-5-[(3-methyl-3H-imidazol-4-ylmrthylene)amino]pentan-3-ol

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Chemical Property of 1-{benzyl-[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}-5-[(3-methyl-3H-imidazol-4-ylmrthylene)amino]pentan-3-ol

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Technology Process of 1-{benzyl-[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}-5-[(3-methyl-3H-imidazol-4-ylmrthylene)amino]pentan-3-ol

There total 12 articles about 1-{benzyl-[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}-5-[(3-methyl-3H-imidazol-4-ylmrthylene)amino]pentan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 13750-81-7
N-methyl-2-imidazolcarboxaldehyde

: 402921-71-5
1-amino-5-{benzyl-[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}pentan-32-ol

: 402921-45-3
1-{benzyl-[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}-5-[(3-methyl-3H-imidazol-4-ylmrthylene)amino]pentan-3-ol

Guidance literature:: In benzene; at 20 ℃; for 0.5h;
DOI:10.1039/b103164n

Reference yield:

: 189440-33-3
(2-aminoethyl)bis(2-pyridylmethyl)amine

: 402921-45-3
1-{benzyl-[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}-5-[(3-methyl-3H-imidazol-4-ylmrthylene)amino]pentan-3-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / MgSO₄ / CH₂Cl₂ / 3 h / 20 °C

2: 91 percent / NaBH₄ / acetonitrile; acetic acid; ethanol / 18 h / 20 °C

3: 97 percent / methanol / 24 h / 20 °C

4: NaBH₄ / methanol / 3 h / 20 °C

5: 17.74 g / aq. HCl / 20 h / 20 °C

6: 96 percent / benzene / 0.5 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; magnesium sulfate; In methanol; ethanol; dichloromethane; acetic acid; acetonitrile; benzene; 3: Michael addition;
DOI:10.1039/b103164n

Reference yield:

: 1121-60-4
pyridine-2-carbaldehyde

: 402921-45-3
1-{benzyl-[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}-5-[(3-methyl-3H-imidazol-4-ylmrthylene)amino]pentan-3-ol

Guidance literature:: Multi-step reaction with 10 steps

1: 100 percent / MgSO₄ / CH₂Cl₂ / 3 h / 20 °C

2: 73 percent / NaBH₄ / acetonitrile; ethanol; acetic acid / 18 h / 20 °C

3: 68 percent / K₂CO₃; KI / acetonitrile / 24 h / Heating

4: 68 percent / hydrazine monohydrate / ethanol / 3 h / Heating

5: 100 percent / MgSO₄ / CH₂Cl₂ / 3 h / 20 °C

6: 91 percent / NaBH₄ / acetonitrile; acetic acid; ethanol / 18 h / 20 °C

7: 97 percent / methanol / 24 h / 20 °C

8: NaBH₄ / methanol / 3 h / 20 °C

9: 17.74 g / aq. HCl / 20 h / 20 °C

10: 96 percent / benzene / 0.5 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; magnesium sulfate; potassium carbonate; hydrazine hydrate; potassium iodide; In methanol; ethanol; dichloromethane; acetic acid; acetonitrile; benzene; 7: Michael addition;
DOI:10.1039/b103164n