Technology Process of (3aR,9bR)-3-benzyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-6,7-diol hydrobromide
There total 11 articles about (3aR,9bR)-3-benzyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-6,7-diol hydrobromide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen bromide;
In
water;
at 120 ℃;
for 0.277778h;
Microwave irradiation;
- Guidance literature:
-
C14H19NO2*ClH; benzyl bromide;
With
sodium carbonate;
In
acetone;
at 100 ℃;
for 0.0277778h;
Microwave irradiation;
With
water; hydrogen bromide;
at 120 ℃;
for 0.277778h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triphenylphosphine; diethylazodicarboxylate / diethyl ether / 0 - 20 °C
1.2: 0.33 h
1.3: pH 12 - 13 / Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Reflux
3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h
4.1: Chiral Pak AD-H / diethylamine; ethanol / 35 °C / 75007.5 Torr / Resolution of racemate
5.1: hydrogenchloride / methanol
6.1: sodium carbonate / acetone / 0.03 h / 100 °C / Microwave irradiation
6.2: 0.28 h / 120 °C / Microwave irradiation
With
hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium carbonate; triphenylphosphine; diethylazodicarboxylate;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; ethyl acetate; diethylamine; acetone;
