N¹-methyl-N⁵-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N¹-(phenylmethyl)pentanediamide

Base Information

• Chemical Name: N¹-methyl-N⁵-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N¹-(phenylmethyl)pentanediamide
• CAS No.: 1621317-99-4
• Molecular Formula: C₃₆H₄₀N₆O₅S
• Molecular Weight: 668.817

Synonyms:N¹-methyl-N⁵-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N¹-(phenylmethyl)pentanediamide

Chemical Property of N¹-methyl-N⁵-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N¹-(phenylmethyl)pentanediamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-methyl-N⁵-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N¹-(phenylmethyl)pentanediamide

There total 8 articles about N¹-methyl-N⁵-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N¹-(phenylmethyl)pentanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

8-amino-3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl][1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (1621317-76-7) + 5-[methyl(phenylmethyl)amino]-5-oxopentanoic acid (940100-44-7) + chloroformic acid ethyl ester (541-41-3) → N1-methyl-N5-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N1-(phenylmethyl)pentanediamide (1621317-99-4)

Guidance literature:

5-[methyl(phenylmethyl)amino]-5-oxopentanoic acid; With triethylamine; In tetrahydrofuran; for 0.0833333h; Heating; Cooling with ice;

chloroformic acid ethyl ester; In tetrahydrofuran; for 1h;

8-amino-3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl][1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione; In tetrahydrofuran; at 20 ℃; for 30h;

DOI:10.1016/j.ejmech.2014.06.057

Reference yield:

C12H8ClN3O4S (1621317-72-3) → N1-methyl-N5-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N1-(phenylmethyl)pentanediamide (1621317-99-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 0.5 h / 160 °C

2.1: hydrazine hydrate / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 0.08 h / Heating; Cooling with ice

3.2: 1 h

3.3: 30 h / 20 °C

With hydrazine hydrate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2014.06.057

Reference yield:

benzyl-methyl-amine (103-67-3) → N1-methyl-N5-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N1-(phenylmethyl)pentanediamide (1621317-99-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / 42 h / 40 °C

2.1: triethylamine / tetrahydrofuran / 0.08 h / Heating; Cooling with ice

2.2: 1 h

2.3: 30 h / 20 °C

With triethylamine; In tetrahydrofuran; toluene;

DOI:10.1016/j.ejmech.2014.06.057

upstream raw materials:

C₁₂H₈ClN₃O₄S

benzyl-methyl-amine

ethyl (3-amino-5-nitrobenzothiophen)-2-carboxylate

8-amino-3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl][1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1621317-99-4 N¹-methyl-N⁵-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N¹-(phenylmethyl)pentanediamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send