3-chloro-4-(4-chlorothiazolo[5,4-c]pyridin-2-yl)-5-fluorobenzonitrile

Base Information

Chemical Name:3-chloro-4-(4-chlorothiazolo[5,4-c]pyridin-2-yl)-5-fluorobenzonitrile
CAS No.:1365992-17-1
Molecular Formula:C₁₃H₄Cl₂FN₃S
Molecular Weight:324.165
Hs Code.:

Synonyms:3-chloro-4-(4-chlorothiazolo[5,4-c]pyridin-2-yl)-5-fluorobenzonitrile

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Chemical Property of 3-chloro-4-(4-chlorothiazolo[5,4-c]pyridin-2-yl)-5-fluorobenzonitrile

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Technology Process of 3-chloro-4-(4-chlorothiazolo[5,4-c]pyridin-2-yl)-5-fluorobenzonitrile

There total 10 articles about 3-chloro-4-(4-chlorothiazolo[5,4-c]pyridin-2-yl)-5-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1365992-16-0
2-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-4-cyano-6-fluorobenzimidoyl chloride

: 1365992-17-1
3-chloro-4-(4-chlorothiazolo[5,4-c]pyridin-2-yl)-5-fluorobenzonitrile

Guidance literature:: 2-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-4-cyano-6-fluorobenzimidoyl chloride; With pyridine; thiourea; In isopropyl alcohol; for 3h; Reflux;

With triethylamine; In isopropyl alcohol; at 20 ℃; for 3h; Reflux;

Reference yield:

: 17282-04-1
2-chloro-3-fluoropyridine

: 1365992-17-1
3-chloro-4-(4-chlorothiazolo[5,4-c]pyridin-2-yl)-5-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 4.67 h / -70 °C

1.2: 2 h / -70 - 20 °C

2.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / Inert atmosphere; Reflux

3.1: thionyl chloride / 65 h / Reflux

4.1: thiourea; pyridine / isopropyl alcohol / 3 h / Reflux

4.2: 3 h / 20 °C / Reflux

With pyridine; thionyl chloride; caesium carbonate; thiourea; lithium diisopropyl amide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; n-heptane; ethylbenzene; isopropyl alcohol;

Reference yield:

: 148639-07-0
2-chloro-3-fluoro-4-iodopyridyne

: 1365992-17-1
3-chloro-4-(4-chlorothiazolo[5,4-c]pyridin-2-yl)-5-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / Inert atmosphere; Reflux

2.1: thionyl chloride / 65 h / Reflux

3.1: thiourea; pyridine / isopropyl alcohol / 3 h / Reflux

3.2: 3 h / 20 °C / Reflux

With pyridine; thionyl chloride; caesium carbonate; thiourea; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; isopropyl alcohol;