Propanedioic acid (phenylmethylen

Base Information

• Chemical Name: Propanedioic acid (phenylmethylen
• CAS No.: 32046-34-7
• Molecular Formula: C18H24 O4
• Molecular Weight: 304.386
• Mol file: 32046-34-7.mol

Synonyms:Malonicacid, benzylidene-, di-tert-butyl ester (8CI); Propanedioic acid,(phenylmethylene)-, bis(1,1-dimethylethyl) ester (9CI)

Chemical Property of Propanedioic acid (phenylmethylen

Chemical Property:

• Boiling Point: 133 - 134 °C (0.4 mmHg)
• PSA: 52.60000
• LogP: 3.75340

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanedioic acid (phenylmethylen

There total 2 articles about Propanedioic acid (phenylmethylen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

t-butyl malonate (541-16-2) + benzaldehyde (100-52-7) → di-tert-butyl 2-benzylidenemalonate (32046-34-7)

Guidance literature:

t-butyl malonate; benzaldehyde; With titanium tetrachloride; In tetrahydrofuran; dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

With 4-methyl-morpholine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c9ob02712b

Reference yield:

→ di-tert-butyl 2-benzylidenemalonate (32046-34-7)

Guidance literature:

Benzylidenmalonsaeure, Isobuten;

Reference yield: 98.0%

methyl 2-(m-chlorobenzylideneamino)acetate (866464-53-1) + di-tert-butyl 2-benzylidenemalonate (32046-34-7) → (2S,3S,5S)-4,4-di-tert-butyl 2-methyl 5-(3-chlorophenyl)-3-phenylpyrrolidine-2,4,4-tricarboxylate (1221507-59-0)

Guidance literature:

With (R)-TF-Biphamphos; silver(I) acetate; potassium carbonate; In dichloromethane; at 20 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1039/b919625k

upstream raw materials:

t-butyl malonate

benzaldehyde

Downstream raw materials:

methyl (S)-(-)-5-oxo-3-phenylhexanoate

(R)-methyl 5-oxo-3-phenylhexanoate

(2S,3S,5S)-4,4-di-tert-butyl 2-methyl 5-(4-fluorophenyl)-3-phenylpyrrolidine-2,4,4-tricarboxylate

(2S,3S,5S)-4,4-di-tert-butyl 2-methyl 5-cyclohexyl-3-phenylpyrrolidine-2,4,4-tricarboxylate