3-O-benzyl-15-(5-trimethylsilylpent-4-ynyl)estrone

Base Information

• Chemical Name: 3-O-benzyl-15-(5-trimethylsilylpent-4-ynyl)estrone
• CAS No.: 1013941-23-5
• Molecular Formula: C₃₃H₄₂O₂Si
• Molecular Weight: 498.781
• Mol file: 1013941-23-5.mol

Synonyms:3-O-benzyl-15-(5-trimethylsilylpent-4-ynyl)estrone

Chemical Property of 3-O-benzyl-15-(5-trimethylsilylpent-4-ynyl)estrone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-benzyl-15-(5-trimethylsilylpent-4-ynyl)estrone

There total 2 articles about 3-O-benzyl-15-(5-trimethylsilylpent-4-ynyl)estrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(14α)-3-benzyloxy-1,3,5(10),15-estratetraen-17-one (138743-03-0) → 3-O-benzyl-15-(5-trimethylsilylpent-4-ynyl)estrone (1013941-23-5)

Guidance literature:

<5-(trimethylsilyl)pent-4-yn-1-yl>magnesium chloride; With copper(l) iodide; lithium chloride; In tetrahydrofuran; at -78 - -77 ℃;

(14α)-3-benzyloxy-1,3,5(10),15-estratetraen-17-one; With chloro-trimethyl-silane; In tetrahydrofuran; at 20 ℃; for 18h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield: 90.0%

<5-(trimethylsilyl)pent-4-yn-1-yl>magnesium chloride (113893-39-3) + (14α)-3-benzyloxy-1,3,5(10),15-estratetraen-17-one (138743-03-0) → 3-O-benzyl-15-(5-trimethylsilylpent-4-ynyl)estrone (1013941-23-5)

Guidance literature:

With hydrogenchloride; copper(l) iodide; lithium chloride; In tetrahydrofuran;

<5-(trimethylsilyl)pent-4-yn-1-yl>magnesium chloride; (14α)-3-benzyloxy-1,3,5(10),15-estratetraen-17-one; With chloro-trimethyl-silane; In tetrahydrofuran; at -78 - -20 ℃; for 18h;

With hydrogenchloride; ammonium chloride; more than 3 stages;

Reference yield: 99.0%

3-O-benzyl-15-(5-trimethylsilylpent-4-ynyl)estrone (1013941-23-5) → 3-O-benzyl-15-(pent-4-ynyl)estrone (1013941-24-6)

Guidance literature:

3-O-benzyl-15-(5-trimethylsilylpent-4-ynyl)estrone; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

With water; In tetrahydrofuran;

upstream raw materials:

(14α)-3-benzyloxy-1,3,5(10),15-estratetraen-17-one

<5-(trimethylsilyl)pent-4-yn-1-yl>magnesium chloride

Downstream raw materials:

3-O-benzyl-15-(pent-4-ynyl)estrone

Refernces

• 1、 -. "Therapeutically Active Triazoles and Their Use". Page/Page column 39. . Retrieved 2008/12/06.