138743-03-0

Basic information

• Product Name: 3-O-Benzyl 15,16-Dehydro Estrone
• Synonyms: 3-O-Benzyl 15,16-Dehydro Estrone;3-(Benzyloxy)-estra-1,3,5(10),15-tetraen-17-one;3-(PhenylMethoxy)-estra-1,3,5(10),15-tetraen-17-one;(13S)-3-(Benzyloxy)-13-methyl-6,7,8,9,11,12,13,14-octahydro-17H-cyclopenta[a]phenanthren-17-on
• CAS NO: 138743-03-0
• Molecular Formula: C₂₅H₂₆O₂
• Molecular Weight: 358.47274
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 138743-03-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Solubility: Chloroform
• CAS DataBase Reference: 3-O-Benzyl 15,16-Dehydro Estrone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-O-Benzyl 15,16-Dehydro Estrone(138743-03-0)
• EPA Substance Registry System: 3-O-Benzyl 15,16-Dehydro Estrone(138743-03-0)

Safety Data

• Hazardous Substances Data: 138743-03-0(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Intermediate in the preparation of Estratrienes.

Upstream product

• 213819-19-3 3-benzyloxy-17-trimethylsilyloxy-estra-1,3,5⁽¹⁰⁾,16-tetraene 
• 53-16-7 Estrone 
• 100-39-0 benzyl bromide 
• 690996-27-1 16-bromo-17,17-ethylenedioxy-3-benzyloxy-estra-1,3,5 ⁽¹⁰⁾-trien-17-one 
• 162784-26-1 17,17-ethylenedioxy-3-benzyloxy-estra-1,3,5 ⁽¹⁰⁾-trien-17-one 
• 858-98-0 3-benzyloxyestra-1,3,5⁽¹⁰⁾-trien-17-one 
• 534572-67-3 3-benzyloxy-17,17-ethylenedioxyestra-1,3,5⁽¹⁰⁾,15-tetraene 

Downstream Products

• 50395-18-1 3-benzyloxy-1,3,5⁽¹⁰⁾,14-estratetraen-17-one 
• 534572-68-4 3-benzyloxy-15β-cyanoestra-1,3,5(10)-trien-17-one 
• 534572-91-3 17α-allyl-3-benzyloxyestra-1,3,5(10),15-tetraen-17β-ol 
• 690996-26-0 3-benzyloxy-estra-1,3,5⁽¹⁰⁾,15-tetraene-17-ol 
• 15183-37-6 15α-hydroxyestriol 
• 690996-25-9 17β-acetyloxy-3-benzyloxy-estra-1,3,5(10),15-tetraene 
• 690996-24-8 17-acetyl-3-benzyl estetrol 
• 690996-23-7 17-acetyl estetrol 
• 1424348-17-3 (15β)-3-(benzyloxy)-15-(nitromethyl)estra-1,3,5(10)-trien-17-one 
• 1424348-14-0 (15β)-3-(benzyloxy)-17-oxoestra-1,3,5(10)-triene-15-carboxylic acid 
• 1013941-23-5 3-O-benzyl-15-(5-trimethylsilylpent-4-ynyl)estrone 
• 1013940-38-9 3-benzyl-15β-vinylestrone 
• 1013941-02-0 3-benzyl-15β-[6-(tetrahydro-pyran-2-yloxy)-hexyl]-estrone 
• 534572-92-4 15α-allyl-3-benzyloxyestra-1,3,5(10)-trien-17-one 

Relevant articles and documents

Process for the preparation of estetrol

The present invention relates to a process for the preparation of estra-1,3,5(10)-trien-3,15α,16α,17β-tetraol (estetrol), via a silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10),16-tetraene, wherein A is a protecting group and B is ―Si(R2)3. The invention further relates to a process for the synthesis of 3-A-oxy-estra-1,3,5(10),15-tetraen-17-one, wherein A is a protecting group, via said silyl enol ether derivative.

SYNTHESIS OF ESTETROL VIA ESTRONE DERIVED STEROIDS

A process is provided for the making of estetrol starting from a 3-A-oxy-estra 1,3,5(10),15-tetraen-17-one, wherein A is an C1-C5 alkyl group, preferably a methyl group, or a C7 - C12 benzylic group, preferably a benzyl group. This process is particularly suitable to industry.

SYNTHESIS OF 17β-ESTRADIOL DERIVATIVES WITH N-BUTYL, N-METHYL ALKYLAMIDE SIDE CHAIN AT POSITION 15

New derivatives of 17-β-estradiol with N-butyl, N-methyl alkylamide side chains of three different lengths at position 15 have been synthesized from estrone.Compounds 5 and 6 having a shorter alkylamide chain were obtained in eleven steps by introduction