6-(3-(piperidin-1-yl)propoxy)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)benzo[d]oxazole

Base Information

Chemical Name:6-(3-(piperidin-1-yl)propoxy)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)benzo[d]oxazole
CAS No.:1219925-74-2
Molecular Formula:C₂₉H₃₉N₃O₃
Molecular Weight:477.647
Hs Code.:

Synonyms:6-(3-(piperidin-1-yl)propoxy)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)benzo[d]oxazole

Suppliers and Price of 6-(3-(piperidin-1-yl)propoxy)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)benzo[d]oxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(3-(piperidin-1-yl)propoxy)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)benzo[d]oxazole

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Technology Process of 6-(3-(piperidin-1-yl)propoxy)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)benzo[d]oxazole

There total 6 articles about 6-(3-(piperidin-1-yl)propoxy)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)benzo[d]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 110-89-4
piperidine

: 1219925-75-3
6-(3-chloropropoxy)-2-(4-(3-chloropropoxy)phenyl)benzo[d]oxazole

: 1219925-74-2
6-(3-(piperidin-1-yl)propoxy)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)benzo[d]oxazole

Guidance literature:: In N,N-dimethyl-formamide; at 110 ℃; for 8h; Sealed tube; Inert atmosphere;
DOI:10.1016/j.ejmech.2017.03.086

Reference yield:

: 100-09-4
4-methoxybenzoic acid

: 1219925-74-2
6-(3-(piperidin-1-yl)propoxy)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)benzo[d]oxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,1'-carbonyldiimidazole / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 0.5 h / 0 - 20 °C

3.1: acetic acid / 48 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / Inert atmosphere

4.2: 12 h / 20 °C / Inert atmosphere

5.1: N,N-dimethyl-formamide / 8 h / 110 °C / Sealed tube; Inert atmosphere

With boron tribromide; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2017.03.086

Reference yield:

: 2735-04-8,161687-55-4
2,4-Dimethoxyaniline

: 1219925-74-2
6-(3-(piperidin-1-yl)propoxy)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)benzo[d]oxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,1'-carbonyldiimidazole / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 0.5 h / 0 - 20 °C

3.1: acetic acid / 48 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / Inert atmosphere

4.2: 12 h / 20 °C / Inert atmosphere

5.1: N,N-dimethyl-formamide / 8 h / 110 °C / Sealed tube; Inert atmosphere

With boron tribromide; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2017.03.086