1219925-75-3

Upstream product

• 100-09-4 4-methoxybenzoic acid 
• 2735-04-8 2,4-Dimethoxyaniline 
• 156086-10-1 N-(2,4-dimethoxyphenyl)-4-methoxybenzamide 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 1345675-25-3 C₂₇H₃₅N₃O₃*2ClH 
• 1219925-73-1 6-[3-(pyrrolidin-1-yl)propoxy]-2-{4-[3-(pyrrolidin-1-yl)propoxy]phenyl}-1,3-benzoxazole 
• 1219925-74-2 6-(3-(piperidin-1-yl)propoxy)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)benzo[d]oxazole 
• 1219962-77-2 C₂₉H₃₉N₃O₃ 

Relevant academic research and scientific papers

Design and development of benzoxazole derivatives with toll-like receptor 9 antagonism

Toll-like receptor 9 (TLR9) is a major therapeutic target for numerous inflammatory disorders. Development of small molecule inhibitors for TLR9 remains largely empirical due to lack of structural understanding of potential TLR9 antagonism by small molecules and due to the unusual topology of the ligand binding surface of the receptor. To develop a structural model for rational design of small molecule TLR9 antagonists, an enhanced homology model of human TLR9 (hTLR9) was constructed. Binding mode analysis of a series of molecules having characteristic molecular geometry, flexibility and basicity was conducted based on crystal structure of the inhibitory DNA (iDNA) bound to horse and bovine TLR9. Interaction with specific amino acid residues in four leucine rich repeat (LRR) regions of TLR9 was identified to be critical for antagonism by small molecules. The biological validation of TLR9 antagonism and its correlation with probe-receptor interactions led to a reliable model that could be used for development of novel small molecules with potent TLR9 antagonism (IC50 30–100?nM) with excellent selectivity against TLR7.

BENZOXAZOLE COMPOUNDS AND METHODS OF USE

The present invention provides benzoxazole compounds and pharmaceutically acceptable salts thereof and pharmaceutical compositions including the same. The present invention further provides methods of use as described herein.

USE OF BENZOXAZOLE COMPOUNDS IN THE TREATMENT OF MALARIA

The present invention provides methods of preventing or treating malaria using benzoxazole compounds. The present invention further provides pharmaceutical compositions including an effective amount of the benzoxazole compounds for the prevention or treatment of malaria.