4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-ol

Base Information

Chemical Name:4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-ol
CAS No.:1190962-53-8
Molecular Formula:C₁₇H₂₀N₄O
Molecular Weight:296.372
Hs Code.:

Synonyms:4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-ol

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Chemical Property of 4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-ol

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Technology Process of 4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-ol

There total 4 articles about 4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190962-52-7
4-(4,4-dimethylcyclohex-1-en-1-yl)-5-(3-methoxy-pyridin-4-yl)-pyrimidin-2-amine

: 1190962-53-8
4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-ol

Guidance literature:: 4-(4,4-dimethylcyclohex-1-en-1-yl)-5-(3-methoxy-pyridin-4-yl)-pyrimidin-2-amine; With pyridine hydrochloride; at 235 ℃; for 3h; oil bath;

With ammonium chloride; In water; ethyl acetate; Saturated solution;

Reference yield:

: 865869-28-9
(4,4-dimethylcyclohex-1-en-1-yl)boronic acid

: 1190962-53-8
4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate / trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran / 25 h / Heating; Reflux; Inert atmosphere

2.1: N-Bromosuccinimide / chloroform-d1 / 1.5 h / 20 °C

3.1: sodium carbonate / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane; water / 135 °C / Inert atmosphere; Autoclave

4.1: pyridine hydrochloride / 3 h / 235 °C / oil bath

4.2: Saturated solution

With potassium phosphate; N-Bromosuccinimide; pyridine hydrochloride; sodium carbonate; trans-bis(triphenylphosphine)palladium dichloride; In tetrahydrofuran; 1,4-dioxane; chloroform-d1; water;

Reference yield:

: 1190962-49-2
4-(4,4-dimethyl-cyclohex-1-en-1-yl)-pyrimidin-2-amine

: 1190962-53-8
4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / chloroform-d1 / 1.5 h / 20 °C

2.1: sodium carbonate / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane; water / 135 °C / Inert atmosphere; Autoclave

3.1: pyridine hydrochloride / 3 h / 235 °C / oil bath

3.2: Saturated solution

With N-Bromosuccinimide; pyridine hydrochloride; sodium carbonate; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; chloroform-d1; water;