4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-yl trifluoromethanesulfonate

Base Information

Chemical Name:4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-yl trifluoromethanesulfonate
CAS No.:1190962-54-9
Molecular Formula:C₁₈H₁₉F₃N₄O₃S
Molecular Weight:428.435
Hs Code.:

Synonyms:4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-yl trifluoromethanesulfonate

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Chemical Property of 4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-yl trifluoromethanesulfonate

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Technology Process of 4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-yl trifluoromethanesulfonate

There total 5 articles about 4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 1190962-53-8
4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-ol

: 1190962-54-9
4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-yl trifluoromethanesulfonate

Guidance literature:: With triethylamine; dmap; In tetrahydrofuran; at 0 - 20 ℃; for 1.58333h;

Reference yield:

: 865869-28-9
(4,4-dimethylcyclohex-1-en-1-yl)boronic acid

: 1190962-54-9
4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate / trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran / 25 h / Heating; Reflux; Inert atmosphere

2.1: N-Bromosuccinimide / chloroform-d1 / 1.5 h / 20 °C

3.1: sodium carbonate / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane; water / 135 °C / Inert atmosphere; Autoclave

4.1: pyridine hydrochloride / 3 h / 235 °C / oil bath

4.2: Saturated solution

5.1: triethylamine / dmap / tetrahydrofuran / 1.58 h / 0 - 20 °C

With potassium phosphate; N-Bromosuccinimide; pyridine hydrochloride; sodium carbonate; triethylamine; dmap; trans-bis(triphenylphosphine)palladium dichloride; In tetrahydrofuran; 1,4-dioxane; chloroform-d1; water;

Reference yield:

: 1190962-50-5
5-bromo-4-(4,4-dimethyl-cyclohex-1-enyl)pyrimidin-2-amine

: 1190962-54-9
4-(2-amino-4-(4,4-dimethylcyclohex-1-en-1-yl)pyrimidin-5-yl)pyridin-3-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane; water / 135 °C / Inert atmosphere; Autoclave

2.1: pyridine hydrochloride / 3 h / 235 °C / oil bath

2.2: Saturated solution

3.1: triethylamine / dmap / tetrahydrofuran / 1.58 h / 0 - 20 °C

With pyridine hydrochloride; sodium carbonate; triethylamine; dmap; trans-bis(triphenylphosphine)palladium dichloride; In tetrahydrofuran; 1,4-dioxane; water;