5-(3,3-dimethyl-but-1-ynyl)-3-[N'-(1,4-dioxa-spiro[4.5]dec-8-yl)-N'-methyl-N-(4-methyl-cyclohexanecarbonyl)-hydrazino]-thiophene-2-carboxylic acid

Base Information

Chemical Name:5-(3,3-dimethyl-but-1-ynyl)-3-[N'-(1,4-dioxa-spiro[4.5]dec-8-yl)-N'-methyl-N-(4-methyl-cyclohexanecarbonyl)-hydrazino]-thiophene-2-carboxylic acid
CAS No.:1315190-83-0
Molecular Formula:C₂₈H₄₀N₂O₅S
Molecular Weight:516.702
Hs Code.:

Synonyms:5-(3,3-dimethyl-but-1-ynyl)-3-[N'-(1,4-dioxa-spiro[4.5]dec-8-yl)-N'-methyl-N-(4-methyl-cyclohexanecarbonyl)-hydrazino]-thiophene-2-carboxylic acid

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Chemical Property of 5-(3,3-dimethyl-but-1-ynyl)-3-[N'-(1,4-dioxa-spiro[4.5]dec-8-yl)-N'-methyl-N-(4-methyl-cyclohexanecarbonyl)-hydrazino]-thiophene-2-carboxylic acid

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Technology Process of 5-(3,3-dimethyl-but-1-ynyl)-3-[N'-(1,4-dioxa-spiro[4.5]dec-8-yl)-N'-methyl-N-(4-methyl-cyclohexanecarbonyl)-hydrazino]-thiophene-2-carboxylic acid

There total 6 articles about 5-(3,3-dimethyl-but-1-ynyl)-3-[N'-(1,4-dioxa-spiro[4.5]dec-8-yl)-N'-methyl-N-(4-methyl-cyclohexanecarbonyl)-hydrazino]-thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1315192-92-7
5-(3,3-Dimethyl-but-1-ynyl)-3-[N'-methyl-N-(4-methyl-cyclohexanecarbonyl)-hydrazino]-thiophene-2-carboxylic acid

: 1315190-83-0
5-(3,3-dimethyl-but-1-ynyl)-3-[N'-(1,4-dioxa-spiro[4.5]dec-8-yl)-N'-methyl-N-(4-methyl-cyclohexanecarbonyl)-hydrazino]-thiophene-2-carboxylic acid

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; for 16h;

Reference yield:

: 1026785-74-9
5-(3,3-dimethyl-but-1-ynyl)-3-(tert-butoxycarbonyl)amino-thiophene-2-carboxylic acid methyl ester

: 1315190-83-0
5-(3,3-dimethyl-but-1-ynyl)-3-[N'-(1,4-dioxa-spiro[4.5]dec-8-yl)-N'-methyl-N-(4-methyl-cyclohexanecarbonyl)-hydrazino]-thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 0.17 h

1.2: 16 h

2.1: diethyl ether / 1 h

2.2: 0.25 h / 60 °C

3.1: dmap / 1,2-dichloro-ethane / 16 h / 40 °C

4.1: potassium tert-butylate / tetrahydrofuran / 16 h / 20 °C

5.1: sodium hydroxide; water / ethyl acetate

6.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h

With dmap; potassium tert-butylate; water; sodium tris(acetoxy)borohydride; acetic acid; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; ethyl acetate; 1,2-dichloro-ethane;

Reference yield:

: 1315192-86-9
3-(N-tert-butoxycarbonyl-hydrazino)-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylic acid methyl ester

: 1315190-83-0
5-(3,3-dimethyl-but-1-ynyl)-3-[N'-(1,4-dioxa-spiro[4.5]dec-8-yl)-N'-methyl-N-(4-methyl-cyclohexanecarbonyl)-hydrazino]-thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether / 1 h

1.2: 0.25 h / 60 °C

2.1: dmap / 1,2-dichloro-ethane / 16 h / 40 °C

3.1: potassium tert-butylate / tetrahydrofuran / 16 h / 20 °C

4.1: sodium hydroxide; water / ethyl acetate

5.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h

With dmap; potassium tert-butylate; water; sodium tris(acetoxy)borohydride; acetic acid; sodium hydroxide; In tetrahydrofuran; diethyl ether; ethyl acetate; 1,2-dichloro-ethane;