Technology Process of 5-Chloro-2-diMethylaMino-phenol
There total 3 articles about 5-Chloro-2-diMethylaMino-phenol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
p-chloro-N,N-dimethylaniline-N-oxide;
With
trifluoroacetic anhydride;
In
dichloromethane;
at -78 ℃;
for 1h;
Inert atmosphere;
With
triethylamine;
In
dichloromethane;
at -78 - 0 ℃;
for 0.25h;
Inert atmosphere;
DOI:10.1021/ol501813s
- Guidance literature:
-
With
dihydrogen peroxide; oxygen; iron(II) sulfate;
In
sulfuric acid; water;
Product distribution;
Mechanism;
Ambient temperature;
pH=2; further objects: pH-dependence (1.8), different substrate concentrations;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 23 °C / Inert atmosphere
2.1: trifluoroacetic anhydride / dichloromethane / 1 h / -78 °C / Inert atmosphere
2.2: 0.25 h / -78 - 0 °C / Inert atmosphere
With
3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride;
In
dichloromethane;
DOI:10.1021/ol501813s
