(E)-N-(4-((6-chloro-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)-3-(pyrrolidin-1-yl)propanamide

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Chemical Name:(E)-N-(4-((6-chloro-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)-3-(pyrrolidin-1-yl)propanamide
CAS No.:1371597-71-5
Molecular Formula:C₂₅H₂₅ClN₄O₂
Molecular Weight:448.952
Hs Code.:

Synonyms:(E)-N-(4-((6-chloro-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)-3-(pyrrolidin-1-yl)propanamide

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Chemical Property of (E)-N-(4-((6-chloro-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)-3-(pyrrolidin-1-yl)propanamide

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Technology Process of (E)-N-(4-((6-chloro-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)-3-(pyrrolidin-1-yl)propanamide

There total 4 articles about (E)-N-(4-((6-chloro-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)-3-(pyrrolidin-1-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.8%

: 123-75-1
pyrrolidine

: 1371597-67-9
(E)-3-chloro-N-(4-((6-chloro-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)propanamide

: 1371597-71-5
(E)-N-(4-((6-chloro-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)-3-(pyrrolidin-1-yl)propanamide

Guidance literature:: With potassium iodide; In ethanol; Reflux;
DOI:10.1016/j.bmc.2012.02.061

Reference yield:

: 1371597-58-8
(E)-6-chloro-3-(4-nitrobenzylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one

: 1371597-71-5
(E)-N-(4-((6-chloro-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)-3-(pyrrolidin-1-yl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodiumsulfide nonahydrate; sodium hydroxide / ethanol; water / 8 h / 90 °C

2: dichloromethane / 6 h / Reflux

3: potassium iodide / ethanol / Reflux

With sodiumsulfide nonahydrate; potassium iodide; sodium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2012.02.061

Reference yield:

: 1371597-65-7
(E)-3-(4-aminobenzylidene)-6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one

: 1371597-71-5
(E)-N-(4-((6-chloro-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)-3-(pyrrolidin-1-yl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 6 h / Reflux

2: potassium iodide / ethanol / Reflux

With potassium iodide; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2012.02.061