3,5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]benzaldehyde

Base Information

• Chemical Name: 3,5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]benzaldehyde
• CAS No.: 412309-96-7
• Molecular Formula: C₄₉H₃₈N₄O₅
• Molecular Weight: 762.865
• Mol file: 412309-96-7.mol

Synonyms:3,5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]benzaldehyde

Chemical Property of 3,5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]benzaldehyde

There total 1 articles about 3,5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

1,2-Dihydro-N-methylcyclohepta[b]pyrrol-2-one (3336-87-6) + benzene-1,3,5-trialdehyde (3163-76-6) → 5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]-1,3-diformylbenzene (412309-95-6) + 3,5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]benzaldehyde (412309-96-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1039/b107962j

Reference yield: 100.0%

1,2-Dihydro-N-phenylcyclohepta[b]pyrrol-2-one (303730-52-1) + 3,5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]benzaldehyde (412309-96-7) → 1,3-bis[bis(1,2-dihydro-N-methyl-2-oxocyclohepta[b]pyrrol-3-yl)methyl]-5-[bis(1,2-dihydro-2-oxo-N-phenylcyclohepta[b]pyrrol-3-yl)methyl]benzene (412310-01-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1039/b107962j

Reference yield:

3,5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]benzaldehyde (412309-96-7) → 1,3-bis[bis(1,2-dihydro-N-methyl-2-oxocyclohepta[b]pyrrol-3-yl)methyliumyl]-5-[bis(1,2-dihydro-2-oxo-N-phenylcyclohepta[b]pyrrol-3-yl)methyliumyl]benzene tris(tetrafluoroborate)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 100 percent / TFA / CH₂Cl₂ / 48 h / 20 °C

2.1: DDQ / CH₂Cl₂ / 1 h / 20 °C

2.2: 100 percent / 42percent HBF₄ / acetic anhydride / 1 h / 0 °C

With trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;

DOI:10.1039/b107962j

upstream raw materials:

1,2-Dihydro-N-methylcyclohepta[b]pyrrol-2-one

benzene-1,3,5-trialdehyde

Downstream raw materials:

1,3-bis[bis(1,2-dihydro-N-methyl-2-oxocyclohepta[b]pyrrol-3-yl)methyl]-5-[bis(1,2-dihydro-2-oxo-N-phenylcyclohepta[b]pyrrol-3-yl)methyl]benzene