5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]-1,3-diformylbenzene

Base Information

• Chemical Name: 5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]-1,3-diformylbenzene
• CAS No.: 412309-95-6
• Molecular Formula: C₂₉H₂₂N₂O₄
• Molecular Weight: 462.505
• Mol file: 412309-95-6.mol

Synonyms:5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]-1,3-diformylbenzene

Chemical Property of 5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]-1,3-diformylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]-1,3-diformylbenzene

There total 1 articles about 5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]-1,3-diformylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

1,2-Dihydro-N-methylcyclohepta[b]pyrrol-2-one (3336-87-6) + benzene-1,3,5-trialdehyde (3163-76-6) → 5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]-1,3-diformylbenzene (412309-95-6) + 3,5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]benzaldehyde (412309-96-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1039/b107962j

Reference yield:

5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]-1,3-diformylbenzene (412309-95-6) → 5-[bis(1,2-dihydro-N-methyl-2-oxocyclohepta[b]pyrrol-3-yl)methyl]-3-[bis(1,2-dihydro-2-oxo-N-phenylcyclohepta[b]pyrrol-3-yl)methyl]-1-[bis(2-oxo-2H-cyclohepta[b]furan-3-yl)methyl]benzene (412310-03-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 25 percent / TFA / CH₂Cl₂ / 48 h / 20 °C

2: 97 percent / TFA / CH₂Cl₂ / 48 h / 20 °C

With trifluoroacetic acid; In dichloromethane;

DOI:10.1039/b107962j

Reference yield:

5-[bis(1,2-dihydro-2-oxo-N-methylcyclohepta[b]pyrrol-3-yl)methyl]-1,3-diformylbenzene (412309-95-6) → 5-[bis(1,2-dihydro-N-methyl-2-oxocyclohepta[b]pyrrol-3-yl)methyliumyl]-3-[bis(1,2-dihydro-2-oxo-N-phenylcyclohepta[b]pyrrol-3-yl)methyliumyl]-1-[bis(2-oxo-2H-cyclohepta[b]furan-3-yl)methyliumyl]benzene tris(tetrafluoroborate)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 25 percent / TFA / CH₂Cl₂ / 48 h / 20 °C

2.1: 97 percent / TFA / CH₂Cl₂ / 48 h / 20 °C

3.1: DDQ / CH₂Cl₂ / 1 h / 20 °C

3.2: 87 percent / 42percent HBF₄ / acetic anhydride / 1 h / 0 °C

With trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;

DOI:10.1039/b107962j

upstream raw materials:

1,2-Dihydro-N-methylcyclohepta[b]pyrrol-2-one

benzene-1,3,5-trialdehyde

Downstream raw materials:

5-[bis(1,2-dihydro-N-methyl-2-oxocyclohepta[b]pyrrol-3-yl)methyl]-3-[bis(1,2-dihydro-2-oxo-N-phenylcyclohepta[b]pyrrol-3-yl)methyl]-1-[bis(2-oxo-2H-cyclohepta[b]furan-3-yl)methyl]benzene