6-(1-(4-bromophenyl)pyrrolidin-3-yloxy)-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 6-(1-(4-bromophenyl)pyrrolidin-3-yloxy)-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 1046816-79-8
• Molecular Formula: C₂₀H₂₃BrN₂O₃S
• Molecular Weight: 451.384

Synonyms:6-(1-(4-bromophenyl)pyrrolidin-3-yloxy)-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 6-(1-(4-bromophenyl)pyrrolidin-3-yloxy)-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of 6-(1-(4-bromophenyl)pyrrolidin-3-yloxy)-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about 6-(1-(4-bromophenyl)pyrrolidin-3-yloxy)-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-bromophenyl)pyrrolidin-3-yl methanesulfonate (1046816-78-7) + 2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-6-ol (1046815-76-2) → 6-(1-(4-bromophenyl)pyrrolidin-3-yloxy)-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline (1046816-79-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 4h;

Reference yield:

6-(1-(4-bromophenyl)pyrrolidin-3-yloxy)-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline (1046816-79-8) + bis(pinacol)diborane (73183-34-3) → 2-(methylsulfonyl)-6-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidin-3-yloxy)-1,2,3,4-tetrahydroisoquinoline (1046816-80-1)

Guidance literature:

With potassium acetate; 1,1'-bis-(diphenylphosphino)ferrocene; In dimethyl sulfoxide; at 80 ℃; for 3h;

upstream raw materials:

1-(4-bromophenyl)pyrrolidin-3-yl methanesulfonate

2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-6-ol

Downstream raw materials:

2-(methylsulfonyl)-6-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidin-3-yloxy)-1,2,3,4-tetrahydroisoquinoline

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