tert-butyl 4-[3-[4-(1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[3-[4-(1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate
CAS No.:1240299-97-1
Molecular Formula:C₂₉H₄₀F₃N₇O₃
Molecular Weight:591.677
Hs Code.:

Synonyms:tert-butyl 4-[3-[4-(1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-[3-[4-(1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate

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Technology Process of tert-butyl 4-[3-[4-(1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate

There total 7 articles about tert-butyl 4-[3-[4-(1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1240299-96-0
tert-butyl 4-[3-[4-[1-(3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]propyl]piperazine-1-carboxylate

: 1240299-97-1
tert-butyl 4-[3-[4-(1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In ethanol; at 78 ℃;

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1240299-97-1
tert-butyl 4-[3-[4-(1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 - 25 °C / Inert atmosphere

4.1: hydrogen / 5%-palladium/activated carbon / methanol / 16 h / 25 °C / 3750.38 Torr

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 80 °C

6.1: ammonium formate / palladium 10% on activated carbon / ethanol / 78 °C

With di-isopropyl azodicarboxylate; hydrogen; ammonium formate; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 132710-90-8
4-(3-hydroxy-propyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1240299-97-1
tert-butyl 4-[3-[4-(1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 - 25 °C / Inert atmosphere

2: hydrogen / 5%-palladium/activated carbon / methanol / 16 h / 25 °C / 3750.38 Torr

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 80 °C

4: ammonium formate / palladium 10% on activated carbon / ethanol / 78 °C

With di-isopropyl azodicarboxylate; hydrogen; ammonium formate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;