2-(4-methoxyphenyl)-1-methyl-3-phenylisoquinolinium iodide

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-1-methyl-3-phenylisoquinolinium iodide
• CAS No.: 1359716-12-3
• Molecular Formula: C₂₃H₂₀NO*I
• Molecular Weight: 453.322
• Mol file: 1359716-12-3.mol

Synonyms:2-(4-methoxyphenyl)-1-methyl-3-phenylisoquinolinium iodide

Chemical Property of 2-(4-methoxyphenyl)-1-methyl-3-phenylisoquinolinium iodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(4-methoxyphenyl)-1-methyl-3-phenylisoquinolinium iodide

There total 3 articles about 2-(4-methoxyphenyl)-1-methyl-3-phenylisoquinolinium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-[1-(2-iodophenyl)ethylidene]-4-methoxyaniline (1359715-98-2) + phenylacetylene (536-74-3) → 2-(4-methoxyphenyl)-1-methyl-3-phenylisoquinolinium iodide (1359716-12-3)

Guidance literature:

With Ni(PPh₃)3Br₂; zinc; In tetrahydrofuran; at 70 ℃; for 2h; regioselective reaction; Inert atmosphere;

DOI:10.1002/asia.201100834

Reference yield:

2-iodoacetophenone (2142-70-3) → 2-(4-methoxyphenyl)-1-methyl-3-phenylisoquinolinium iodide (1359716-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / toluene / 10 h / Inert atmosphere; Reflux; Molecular sieve

2: Ni(PPh₃)3Br₂; zinc / tetrahydrofuran / 2 h / 70 °C / Inert atmosphere

With pyridine; Ni(PPh₃)3Br₂; zinc; In tetrahydrofuran; toluene;

DOI:10.1002/asia.201100834

Reference yield:

4-methoxy-aniline (104-94-9) → 2-(4-methoxyphenyl)-1-methyl-3-phenylisoquinolinium iodide (1359716-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / toluene / 10 h / Inert atmosphere; Reflux; Molecular sieve

2: Ni(PPh₃)3Br₂; zinc / tetrahydrofuran / 2 h / 70 °C / Inert atmosphere

With pyridine; Ni(PPh₃)3Br₂; zinc; In tetrahydrofuran; toluene;

DOI:10.1002/asia.201100834

upstream raw materials:

N-[1-(2-iodophenyl)ethylidene]-4-methoxyaniline

phenylacetylene

2-iodoacetophenone

4-methoxy-aniline