(S)-2-(4,4-bis(4-fluorophenyl)-2-oxo-5-phenylimidazolidin-1-yl)-N,N-bis(2,4-dimethoxybenzyl)acetamide

Base Information

Chemical Name:(S)-2-(4,4-bis(4-fluorophenyl)-2-oxo-5-phenylimidazolidin-1-yl)-N,N-bis(2,4-dimethoxybenzyl)acetamide
CAS No.:1609285-04-2
Molecular Formula:C₄₁H₃₉F₂N₃O₆
Molecular Weight:707.774
Hs Code.:

Synonyms:(S)-2-(4,4-bis(4-fluorophenyl)-2-oxo-5-phenylimidazolidin-1-yl)-N,N-bis(2,4-dimethoxybenzyl)acetamide

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Chemical Property of (S)-2-(4,4-bis(4-fluorophenyl)-2-oxo-5-phenylimidazolidin-1-yl)-N,N-bis(2,4-dimethoxybenzyl)acetamide

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Technology Process of (S)-2-(4,4-bis(4-fluorophenyl)-2-oxo-5-phenylimidazolidin-1-yl)-N,N-bis(2,4-dimethoxybenzyl)acetamide

There total 4 articles about (S)-2-(4,4-bis(4-fluorophenyl)-2-oxo-5-phenylimidazolidin-1-yl)-N,N-bis(2,4-dimethoxybenzyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1609285-03-1
(S)-4,4-bis(4-fluorophenyl)-5-phenylimidazolidin-2-one

: 1609285-21-3
2-chloro-N,N-bis(2,4-dimethoxybenzyl)acetamide

: 1609285-04-2
(S)-2-(4,4-bis(4-fluorophenyl)-2-oxo-5-phenylimidazolidin-1-yl)-N,N-bis(2,4-dimethoxybenzyl)acetamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 2h;

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 1609285-04-2
(S)-2-(4,4-bis(4-fluorophenyl)-2-oxo-5-phenylimidazolidin-1-yl)-N,N-bis(2,4-dimethoxybenzyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 20 °C / Cooling with ice

2: dichloromethane / 1 h

3: boron trifluoride diethyl etherate / dichloromethane / 3 h / 50 °C / Sealed tube

4: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C

With boron trifluoride diethyl etherate; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;

Reference yield:

: 1609285-02-0
(S)-1-(2,2-bis(4-fluorophenyl)-2-hydroxy-1-phenylethyl)-3-(2,4-dimethoxybenzyl)urea

: 1609285-04-2
(S)-2-(4,4-bis(4-fluorophenyl)-2-oxo-5-phenylimidazolidin-1-yl)-N,N-bis(2,4-dimethoxybenzyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / dichloromethane / 3 h / 50 °C / Sealed tube

2: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C

With boron trifluoride diethyl etherate; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;