ethyl 2-[2,4-difluoro-3-[[5-(3-fluorophenyl)-2-methoxy-3-methyl-phenyl]methylamino]phenoxy]acetate

Base Information

Chemical Name:ethyl 2-[2,4-difluoro-3-[[5-(3-fluorophenyl)-2-methoxy-3-methyl-phenyl]methylamino]phenoxy]acetate
CAS No.:1427407-45-1
Molecular Formula:C₂₅H₂₄F₃NO₄
Molecular Weight:459.465
Hs Code.:

Synonyms:ethyl 2-[2,4-difluoro-3-[[5-(3-fluorophenyl)-2-methoxy-3-methyl-phenyl]methylamino]phenoxy]acetate

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Chemical Property of ethyl 2-[2,4-difluoro-3-[[5-(3-fluorophenyl)-2-methoxy-3-methyl-phenyl]methylamino]phenoxy]acetate

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Technology Process of ethyl 2-[2,4-difluoro-3-[[5-(3-fluorophenyl)-2-methoxy-3-methyl-phenyl]methylamino]phenoxy]acetate

There total 8 articles about ethyl 2-[2,4-difluoro-3-[[5-(3-fluorophenyl)-2-methoxy-3-methyl-phenyl]methylamino]phenoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1427407-44-0
2,4-difluoro-3-[[5-(3-fluorophenyl)-2-methoxy-3-methylphenyl]methylamino]phenol

: 105-36-2
ethyl bromoacetate

: 1427407-45-1
ethyl 2-[2,4-difluoro-3-[[5-(3-fluorophenyl)-2-methoxy-3-methyl-phenyl]methylamino]phenoxy]acetate

Guidance literature:: 2,4-difluoro-3-[[5-(3-fluorophenyl)-2-methoxy-3-methylphenyl]methylamino]phenol; With caesium carbonate; In acetone; at 20 ℃; for 0.5h;

ethyl bromoacetate; In acetone; at 20 ℃; for 1h;

Reference yield:

: 722497-32-7
methyl 5-bromo-2-methoxy-3-methyl-benzoate

: 1427407-45-1
ethyl 2-[2,4-difluoro-3-[[5-(3-fluorophenyl)-2-methoxy-3-methyl-phenyl]methylamino]phenoxy]acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; sodium hydroxide / tetrahydrofuran / 5 h / 20 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol; N,N-dimethyl-formamide / 100 °C

3.1: thionyl chloride / 6 h / 70 °C

4.1: sodium hydrogencarbonate / tetrahydrofuran / 2 h / 0 - 20 °C

5.1: borane-THF / tetrahydrofuran / 0 - 60 °C

6.1: caesium carbonate / acetone / 0.5 h / 20 °C

6.2: 1 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; borane-THF; water; sodium hydrogencarbonate; sodium carbonate; caesium carbonate; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 83-40-9
3-methylsalicylic acid

: 1427407-45-1
ethyl 2-[2,4-difluoro-3-[[5-(3-fluorophenyl)-2-methoxy-3-methyl-phenyl]methylamino]phenoxy]acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid; bromine / 24 h / 20 °C

2.1: potassium carbonate; caesium carbonate / N,N-dimethyl-formamide; acetone / 20 - 58 °C

3.1: water; sodium hydroxide / tetrahydrofuran / 5 h / 20 °C

4.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol; N,N-dimethyl-formamide / 100 °C

5.1: thionyl chloride / 6 h / 70 °C

6.1: sodium hydrogencarbonate / tetrahydrofuran / 2 h / 0 - 20 °C

7.1: borane-THF / tetrahydrofuran / 0 - 60 °C

8.1: caesium carbonate / acetone / 0.5 h / 20 °C

8.2: 1 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; borane-THF; water; bromine; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; caesium carbonate; acetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetone;