(5-chloroimidazo[1,2-a]pyridin-8-yl)-[4-(4-isopropylpiperazin-1-yl)phenyl]amine

Base Information

Chemical Name:(5-chloroimidazo[1,2-a]pyridin-8-yl)-[4-(4-isopropylpiperazin-1-yl)phenyl]amine
CAS No.:1031290-25-1
Molecular Formula:C₂₀H₂₄ClN₅
Molecular Weight:369.897
Hs Code.:

Synonyms:(5-chloroimidazo[1,2-a]pyridin-8-yl)-[4-(4-isopropylpiperazin-1-yl)phenyl]amine

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Chemical Property of (5-chloroimidazo[1,2-a]pyridin-8-yl)-[4-(4-isopropylpiperazin-1-yl)phenyl]amine

Chemical Property:

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Technology Process of (5-chloroimidazo[1,2-a]pyridin-8-yl)-[4-(4-isopropylpiperazin-1-yl)phenyl]amine

There total 9 articles about (5-chloroimidazo[1,2-a]pyridin-8-yl)-[4-(4-isopropylpiperazin-1-yl)phenyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 443914-86-1
4-(4-(2-propyl)-piperazin-1-yl)aniline

: 1031289-77-6
5-chloro-8-iodo-imidazo[1,2-a]pyridine

: 1031290-25-1
(5-chloroimidazo[1,2-a]pyridin-8-yl)-[4-(4-isopropylpiperazin-1-yl)phenyl]amine

Guidance literature:: With caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 20 ℃; for 16h; Heating / reflux;

Reference yield:

: 800402-06-6
6-chloro-3-iodo-pyridin-2-ylamine

: 1031290-25-1
(5-chloroimidazo[1,2-a]pyridin-8-yl)-[4-(4-isopropylpiperazin-1-yl)phenyl]amine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide / water; isopropyl alcohol / 12 h / Heating / reflux

2: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 20 °C / Heating / reflux

With hydrogen bromide; caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In water; isopropyl alcohol; toluene; 2: Buchwald coupling;

Reference yield:

: 132784-74-8
2-amino-6-trimethylacetamidopyridine

: 1031290-25-1
(5-chloroimidazo[1,2-a]pyridin-8-yl)-[4-(4-isopropylpiperazin-1-yl)phenyl]amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / water / -20 - 0 °C

1.2: 4 h / -20 - 20 °C

1.3: pH 9 - 10

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 4 h / -80 °C

2.2: 2 h / -80 - 20 °C

3.1: hydrogenchloride; water / 5 h / Heating / reflux

4.1: hydrogen bromide / water; isopropyl alcohol / 12 h / Heating / reflux

5.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 20 °C / Heating / reflux

With hydrogenchloride; water; hydrogen bromide; tert.-butyl lithium; caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; water; isopropyl alcohol; toluene; pentane; 5.1: Buchwald coupling;