Technology Process of cyclopentyl N-[3-(2-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)propyl]-L-leucinate
There total 10 articles about cyclopentyl N-[3-(2-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)propyl]-L-leucinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen; potassium carbonate;
palladium 10% on activated carbon;
In
ethyl acetate;
for 18h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hydroxide; methanol / 20 h / 75 °C
1.2: 0.5 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 100 h / 20 °C
3.1: Wilkinson's catalyst / ethyl acetate / 20 °C
4.1: Dess-Martin periodane / dichloromethane / 1.5 h
5.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 1.5 h
6.1: potassium carbonate; hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h
With
methanol; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
dmap; Wilkinson's catalyst; palladium 10% on activated carbon;
In
1,1-dichloroethane; dichloromethane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: dmap / 1 h / 55 °C
2.1: trifluorormethanesulfonic acid / toluene / 2.5 h / 20 °C / Cooling with ice
2.2: 18 h / 20 °C
3.1: potassium carbonate / acetonitrile / 42 h / 75 °C
4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h
4.2: 0.5 h
5.1: potassium hydroxide; methanol / 20 h / 75 °C
5.2: 0.5 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 100 h / 20 °C
7.1: Wilkinson's catalyst / ethyl acetate / 20 °C
8.1: Dess-Martin periodane / dichloromethane / 1.5 h
9.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 1.5 h
10.1: potassium carbonate; hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h
With
methanol; trifluorormethanesulfonic acid; potassium tert-butylate; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
dmap; Wilkinson's catalyst; palladium 10% on activated carbon;
In
tetrahydrofuran; 1,1-dichloroethane; dichloromethane; ethyl acetate; toluene; acetonitrile;
![cyclopentyl N-[3-(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)propyl]-L-leucinate](/Databaselist/images/loading.webp)
