(3S)-3-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]-3-phenylpropan-1-ol

Base Information

Chemical Name:(3S)-3-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]-3-phenylpropan-1-ol
CAS No.:1260396-14-2
Molecular Formula:C₁₇H₁₈N₄O₂S
Molecular Weight:342.422
Hs Code.:

Synonyms:(3S)-3-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]-3-phenylpropan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S)-3-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]-3-phenylpropan-1-ol

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Technology Process of (3S)-3-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]-3-phenylpropan-1-ol

There total 2 articles about (3S)-3-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]-3-phenylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₆N₄O₂S

: 1260396-14-2
(3S)-3-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]-3-phenylpropan-1-ol

Guidance literature:: With lithium borohydride; In methanol; toluene; at -78 - -30 ℃; for 1.5h;
DOI:10.1021/ol102892f

Reference yield:

: 13980-76-2
1-(4-methoxyphenyl)-1H-tetrazole-5-thiol

: 104-55-2
3-phenyl-propenal

: 1260396-14-2
(3S)-3-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]-3-phenylpropan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; benzoic acid / toluene / 0.5 h / -60 °C

1.2: 92 h / -60 °C

2.1: lithium borohydride / methanol; toluene / 1.5 h / -78 - -30 °C

With (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; lithium borohydride; benzoic acid; In methanol; toluene; 1.1: aza-Michael reaction / 1.2: aza-Michael reaction;
DOI:10.1021/ol102892f