2-<2,2-bis(methylthio)ethyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

Base Information

Chemical Name:2-<2,2-bis(methylthio)ethyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole
CAS No.:101481-24-7
Molecular Formula:C₂₅H₃₀N₂O₂S₃
Molecular Weight:486.723
Hs Code.:

Synonyms:2-<2,2-bis(methylthio)ethyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

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Chemical Property of 2-<2,2-bis(methylthio)ethyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

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Technology Process of 2-<2,2-bis(methylthio)ethyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

There total 4 articles about 2-<2,2-bis(methylthio)ethyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 74-93-1
methylthiol

: 101481-27-0
2-(2,2-diethoxyethyl)-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

: 101481-24-7
2-<2,2-bis(methylthio)ethyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; for 24h; Ambient temperature;
DOI:10.1021/jo00313a017

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 101481-24-7
2-<2,2-bis(methylthio)ethyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

Guidance literature:: Multi-step reaction with 2 steps

1: 50percent NaOH / Bu₄N*HSO₄ / benzene

2: BF₃*Et₂O / CH₂Cl₂

With sodium hydroxide; boron trifluoride diethyl etherate; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; benzene;
DOI:10.1016/S0040-4039(00)94994-3

Reference yield:

: 99552-97-3
1,2,3,4,5,6-hexahydro-1,5-methaneoazacino<4,3-b>indole

: 101481-24-7
2-<2,2-bis(methylthio)ethyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

Guidance literature:: Multi-step reaction with 3 steps

1: Na₂CO₃ / dioxane / Heating

2: 50percent NaOH / Bu₄N*HSO₄ / benzene

3: BF₃*Et₂O / CH₂Cl₂

With sodium hydroxide; boron trifluoride diethyl etherate; sodium carbonate; tetra(n-butyl)ammonium hydrogensulfate; In 1,4-dioxane; dichloromethane; benzene;
DOI:10.1016/S0040-4039(00)94994-3