methyl 3-(8-bromo-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)-4-chlorobenzoate

Base Information

Chemical Name:methyl 3-(8-bromo-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)-4-chlorobenzoate
CAS No.:1282529-97-8
Molecular Formula:C₂₂H₁₇BrClNO₄S
Molecular Weight:506.804
Hs Code.:

Synonyms:methyl 3-(8-bromo-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)-4-chlorobenzoate

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Chemical Property of methyl 3-(8-bromo-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)-4-chlorobenzoate

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Technology Process of methyl 3-(8-bromo-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)-4-chlorobenzoate

There total 11 articles about methyl 3-(8-bromo-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)-4-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1282529-96-7
methyl 3-(8-bromo-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)-4-chlorobenzoate

: 74-88-4
methyl iodide

: 1282529-97-8
methyl 3-(8-bromo-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)-4-chlorobenzoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm2007084

Reference yield:

: 157245-84-6
ethyl 4-(3-bromophenoxy)butanoate

: 1282529-97-8
methyl 3-(8-bromo-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)-4-chlorobenzoate

Guidance literature:: Multi-step reaction with 8 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran / 48 h / 50 °C

2: polyphosphoric acid; celite / toluene / 5 h / 110 °C

3: N,N-dimethyl-formamide / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 50 °C

5: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 50 °C

6: thionyl chloride / 2 h / 80 °C

7: pyridine / tetrahydrofuran / 20 °C

8: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With pyridine; thionyl chloride; lithium hydroxide monohydrate; water; potassium carbonate; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm2007084

Reference yield:

: 1189815-76-6
methyl 8-bromo-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxylate

: 1282529-97-8
methyl 3-(8-bromo-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)-4-chlorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 50 °C

2: thionyl chloride / 2 h / 80 °C

3: pyridine / tetrahydrofuran / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With pyridine; thionyl chloride; lithium hydroxide monohydrate; water; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm2007084