N-tert-butoxy-3-[1,3-dioxo-2-(1-phenyl-ethyl)-2,3-dihydro-1H-isoindol-5-yl]-acrylamide

Base Information

Chemical Name:N-tert-butoxy-3-[1,3-dioxo-2-(1-phenyl-ethyl)-2,3-dihydro-1H-isoindol-5-yl]-acrylamide
CAS No.:930296-13-2
Molecular Formula:C₂₃H₂₄N₂O₄
Molecular Weight:392.455
Hs Code.:

<i>N</i>-<i>tert</i>-butoxy-3-[1,3-dioxo-2-(1-phenyl-ethyl)-2,3-dihydro-1<i>H</i>-isoindol-5-yl]-acrylamide

Synonyms:N-tert-butoxy-3-[1,3-dioxo-2-(1-phenyl-ethyl)-2,3-dihydro-1H-isoindol-5-yl]-acrylamide

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Chemical Property of N-tert-butoxy-3-[1,3-dioxo-2-(1-phenyl-ethyl)-2,3-dihydro-1H-isoindol-5-yl]-acrylamide

Chemical Property:

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Technology Process of N-tert-butoxy-3-[1,3-dioxo-2-(1-phenyl-ethyl)-2,3-dihydro-1H-isoindol-5-yl]-acrylamide

There total 6 articles about N-tert-butoxy-3-[1,3-dioxo-2-(1-phenyl-ethyl)-2,3-dihydro-1H-isoindol-5-yl]-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27550-59-0
4-hydroxyphthalic anhydride

: 930296-13-2
N-tert-butoxy-3-[1,3-dioxo-2-(1-phenyl-ethyl)-2,3-dihydro-1H-isoindol-5-yl]-acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: Heating

2.1: triethylamine / toluene / 20 °C

3.1: (P(Ph)3)2PdCl₂; triethylamine / dimethylformamide

4.1: aq. HCl; acetic acid / Heating

5.1: ClCO₂Et; triethylamine / tetrahydrofuran / 0 °C

5.2: methanol / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; chloroformic acid ethyl ester; acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2005.07.048

Reference yield:

: 203788-60-7
5-Hydroxy-2-((S)-1-phenyl-ethyl)-isoindole-1,3-dione

: 930296-13-2
N-tert-butoxy-3-[1,3-dioxo-2-(1-phenyl-ethyl)-2,3-dihydro-1H-isoindol-5-yl]-acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / toluene / 20 °C

2.1: triethylamine / (PPh₃)2PdCl₂ / dimethylformamide / Heating

3.1: acetic acid; hydrochloric acid / Heating

4.1: ethyl chloroformate; triethylamine / tetrahydrofuran / 0 °C

4.2: tetrahydrofuran; methanol / 20 °C

With hydrogenchloride; chloroformic acid ethyl ester; acetic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 2.1: Heck reaction;
DOI:10.1016/j.bmc.2006.07.008

Reference yield:

: 888701-19-7
trifluoro-methanesulfonic acid 1,3-dioxo-2-(1-phenyl-ethyl)-2,3-dihydro-1H-isoindol-5-yl ester

: 930296-13-2
N-tert-butoxy-3-[1,3-dioxo-2-(1-phenyl-ethyl)-2,3-dihydro-1H-isoindol-5-yl]-acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / (PPh₃)2PdCl₂ / dimethylformamide / Heating

2.1: acetic acid; hydrochloric acid / Heating

3.1: ethyl chloroformate; triethylamine / tetrahydrofuran / 0 °C

3.2: tetrahydrofuran; methanol / 20 °C

With hydrogenchloride; chloroformic acid ethyl ester; acetic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Heck reaction;
DOI:10.1016/j.bmc.2006.07.008