5-bromo-3-(5-methoxy-pyridin-2-yl)-2-methyl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Name:5-bromo-3-(5-methoxy-pyridin-2-yl)-2-methyl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1351478-18-6
Molecular Formula:C₂₁H₁₈BrN₃O₃S
Molecular Weight:472.362
Hs Code.:

Synonyms:5-bromo-3-(5-methoxy-pyridin-2-yl)-2-methyl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 5-bromo-3-(5-methoxy-pyridin-2-yl)-2-methyl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 5-bromo-3-(5-methoxy-pyridin-2-yl)-2-methyl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

There total 7 articles about 5-bromo-3-(5-methoxy-pyridin-2-yl)-2-methyl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1351478-10-8
5-bromo-3-iodo-2-methyl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1142944-78-2
(5-methoxypyridine-2-yl)boronic acid

: 1351478-18-6
5-bromo-3-(5-methoxy-pyridin-2-yl)-2-methyl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With caesium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In N,N-dimethyl-formamide; at 150 ℃; for 1h; Microwave irradiation;

Reference yield: 50.0%

: 1351478-10-8
5-bromo-3-iodo-2-methyl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1333505-99-9
(4-methoxy-2-pyridyl)boronic acid

: 1351478-18-6
5-bromo-3-(5-methoxy-pyridin-2-yl)-2-methyl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; caesium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1351478-18-6
5-bromo-3-(5-methoxy-pyridin-2-yl)-2-methyl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 1.5 h / 0 °C

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -40 - -35 °C

2.2: 2 h / -35 - 20 °C

3.1: caesium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 1 h / 150 °C / Microwave irradiation

With n-butyllithium; sodium hydride; caesium carbonate; diisopropylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; mineral oil;