6-(4-Ethoxy-phenyl)-4-(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-2H-pyridazine-3-thione

Base Information

• Chemical Name: 6-(4-Ethoxy-phenyl)-4-(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-2H-pyridazine-3-thione
• CAS No.: 135128-66-4
• Molecular Formula: C₂₂H₂₀N₄OS₂
• Molecular Weight: 420.559
• Mol file: 135128-66-4.mol

Synonyms:6-(4-Ethoxy-phenyl)-4-(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-2H-pyridazine-3-thione

Chemical Property of 6-(4-Ethoxy-phenyl)-4-(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-2H-pyridazine-3-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-Ethoxy-phenyl)-4-(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-2H-pyridazine-3-thione

There total 4 articles about 6-(4-Ethoxy-phenyl)-4-(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-2H-pyridazine-3-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

6-(p-Ethoxyphenyl)-4-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-4,5-dihydro-3(2H)-pyridazinone (135128-61-9) → 6-(4-Ethoxy-phenyl)-4-(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-2H-pyridazine-3-thione (135128-66-4)

Guidance literature:

With tetraphosphorus decasulfide; In xylene; for 6h; Heating;

DOI:10.1246/bcsj.64.2032

Reference yield:

(E)-4-(4-ethoxyphenyl)-4-oxobut-2-enoic acid (29582-31-8) → 6-(4-Ethoxy-phenyl)-4-(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-2H-pyridazine-3-thione (135128-66-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 46 percent / benzene / 10 h / Heating

2: 60 percent / hydrazine hydrate / ethanol / 5 h / Heating

3: 69 percent / P₂S₅ / xylene / 6 h / Heating

With tetraphosphorus decasulfide; hydrazine hydrate; In ethanol; xylene; benzene;

DOI:10.1246/bcsj.64.2032

Reference yield:

4,5-Dihydro-α-<2-(4-ethoxyphenyl)-2-oxoethyl>-3-methyl-5-oxo-1-phenyl-1H-pyrazole-4-acetic acid (135128-60-8) → 6-(4-Ethoxy-phenyl)-4-(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-2H-pyridazine-3-thione (135128-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / hydrazine hydrate / ethanol / 5 h / Heating

2: 69 percent / P₂S₅ / xylene / 6 h / Heating

With tetraphosphorus decasulfide; hydrazine hydrate; In ethanol; xylene;

DOI:10.1246/bcsj.64.2032

upstream raw materials:

6-(p-Ethoxyphenyl)-4-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-4,5-dihydro-3(2H)-pyridazinone

(E)-4-(4-ethoxyphenyl)-4-oxobut-2-enoic acid

4,5-Dihydro-α-<2-(4-ethoxyphenyl)-2-oxoethyl>-3-methyl-5-oxo-1-phenyl-1H-pyrazole-4-acetic acid

edaravone

Downstream raw materials:

8-(4-Ethoxy-phenyl)-1-methyl-3-phenyl-3H-4,5-dithia-2,3,6,7-tetraaza-cyclopenta[a]naphthalene