N'-Cyclohexylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinecarboxylic acid tert-butyl ester

Base Information

Chemical Name:N'-Cyclohexylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinecarboxylic acid tert-butyl ester
CAS No.:180462-96-8
Molecular Formula:C₂₉H₄₈N₄O₆
Molecular Weight:548.723
Hs Code.:

N'-Cyclohexylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinecarboxylic acid tert-butyl ester

Synonyms:N'-Cyclohexylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinecarboxylic acid tert-butyl ester

Suppliers and Price of N'-Cyclohexylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinecarboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N'-Cyclohexylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N'-Cyclohexylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinecarboxylic acid tert-butyl ester

There total 7 articles about N'-Cyclohexylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870-46-2
t-butoxycarbonylhydrazine

: 180462-96-8
N'-Cyclohexylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / ethanol / 3 h / Heating

2: 95 percent / H₂ / 5percent Pt/C / methanol / 8 h / 760 Torr / Ambient temperature

3: 61 percent / methanol / 16 h / Heating

4: 95 percent / 1 N aq. K₂CO₃ / methanol / 16 h / Heating

5: 1.) 1-ethyl-3-(3-diaminopropyl)carbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate, triethylamine / 1.) DMF, 30 min, 2.) DMF, RT, 16 h

With 1-ethyl-3-(3-diaminopropyl)carbodiimide hydrochloride; hydrogen; potassium carbonate; 1-hydroxybenzotriazol-hydrate; triethylamine; platinum on activated charcoal; In methanol; ethanol;
DOI:10.1021/jm960022p

Reference yield:

: 929016-50-2
(E)-tert-butyl 2-(cyclohexylmethylene)hydrazinecarboxylate

: 180462-96-8
N'-Cyclohexylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / H₂ / 5percent Pt/C / methanol / 8 h / 760 Torr / Ambient temperature

2: 61 percent / methanol / 16 h / Heating

3: 95 percent / 1 N aq. K₂CO₃ / methanol / 16 h / Heating

4: 1.) 1-ethyl-3-(3-diaminopropyl)carbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate, triethylamine / 1.) DMF, 30 min, 2.) DMF, RT, 16 h

With 1-ethyl-3-(3-diaminopropyl)carbodiimide hydrochloride; hydrogen; potassium carbonate; 1-hydroxybenzotriazol-hydrate; triethylamine; platinum on activated charcoal; In methanol;
DOI:10.1021/jm960022p

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 180462-96-8
N'-Cyclohexylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / ethanol / 3 h / Heating

2: 95 percent / H₂ / 5percent Pt/C / methanol / 8 h / 760 Torr / Ambient temperature

3: 61 percent / methanol / 16 h / Heating

4: 95 percent / 1 N aq. K₂CO₃ / methanol / 16 h / Heating

5: 1.) 1-ethyl-3-(3-diaminopropyl)carbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate, triethylamine / 1.) DMF, 30 min, 2.) DMF, RT, 16 h

With 1-ethyl-3-(3-diaminopropyl)carbodiimide hydrochloride; hydrogen; potassium carbonate; 1-hydroxybenzotriazol-hydrate; triethylamine; platinum on activated charcoal; In methanol; ethanol;
DOI:10.1021/jm960022p