1-(4-cyanobenzyl)-6-methyl-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid cyanomethylamide

Base Information

Chemical Name:1-(4-cyanobenzyl)-6-methyl-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid cyanomethylamide
CAS No.:1571135-06-2
Molecular Formula:C₂₄H₁₇F₃N₄O₂
Molecular Weight:450.42
Hs Code.:

Synonyms:1-(4-cyanobenzyl)-6-methyl-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid cyanomethylamide

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Chemical Property of 1-(4-cyanobenzyl)-6-methyl-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid cyanomethylamide

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Technology Process of 1-(4-cyanobenzyl)-6-methyl-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid cyanomethylamide

There total 5 articles about 1-(4-cyanobenzyl)-6-methyl-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid cyanomethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1570079-33-2
1-(4-cyano-benzyl)-6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid

: 540-61-4
2-aminoacetonitrile

: 1571135-06-2
1-(4-cyanobenzyl)-6-methyl-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid cyanomethylamide

Guidance literature:: With 4-methyl-morpholine; 1-propanephosphonic acid cylic anhydride; In dichloromethane; ethyl acetate; at 0 - 20 ℃; for 3h;

Reference yield:

: 1570079-68-3
1-(4-cyano-benzyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid

: 1571135-06-2
1-(4-cyanobenzyl)-6-methyl-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid cyanomethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; bromine / 120 h / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane / 72 h / 80 °C

3: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 4-methyl-morpholine / dichloromethane; ethyl acetate / 3 h / 0 - 20 °C

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bromine; caesium carbonate; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In 1,4-dioxane; dichloromethane; ethyl acetate; 2: |Suzuki Coupling;

Reference yield:

: 1570080-14-6
5-bromo-1-(4-cyano-benzyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid

: 1571135-06-2
1-(4-cyanobenzyl)-6-methyl-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid cyanomethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane / 72 h / 80 °C

2: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 4-methyl-morpholine / dichloromethane; ethyl acetate / 3 h / 0 - 20 °C

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In 1,4-dioxane; dichloromethane; ethyl acetate; 1: |Suzuki Coupling;