Benzyl-[5,7-bis-(2-amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-amine

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Chemical Name:Benzyl-[5,7-bis-(2-amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-amine
CAS No.:878020-40-7
Molecular Formula:C₂₆H₂₂N₁₀O
Molecular Weight:490.527
Hs Code.:

Synonyms:Benzyl-[5,7-bis-(2-amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-amine

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Chemical Property of Benzyl-[5,7-bis-(2-amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-amine

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Technology Process of Benzyl-[5,7-bis-(2-amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-amine

There total 6 articles about Benzyl-[5,7-bis-(2-amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: (E)-9-(N-benzylamino)-5,7-bis[(N,N-dimethylamino)-2-propenon-1-yl]-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

: 50-01-1
guanidine hydrochloride

: 878020-40-7
Benzyl-[5,7-bis-(2-amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-amine

Guidance literature:: With potassium carbonate; In 2-methoxy-ethanol; at 100 ℃; for 40h;
DOI:10.1021/jm051090r

Reference yield:

: 878020-37-2
1-[5,7-bis(acetyl-9-(N-benzylamino))]-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

: 878020-40-7
Benzyl-[5,7-bis-(2-amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / dimethylformamide / 24 h / 40 °C

2: 92 percent / dimethylformamide / 12 h / 100 °C

3: 79 percent / K₂CO₃ / 2-methoxy-ethanol / 40 h / 100 °C

With potassium carbonate; In 2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm051090r

Reference yield:

: 492438-69-4
9-benzylamino-7-ethoxycarbonyl-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

: 878020-40-7
Benzyl-[5,7-bis-(2-amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / aq. LiOH / tetrahydrofuran

2.1: 62 percent / tetrahydrofuran / -15 °C

3.1: POCl₃ / CHCl₃ / 0.42 h / 20 °C

3.2: 61 percent / CHCl₃ / 30 h / 70 °C

4.1: 95 percent / dimethylformamide / 24 h / 40 °C

5.1: 92 percent / dimethylformamide / 12 h / 100 °C

6.1: 79 percent / K₂CO₃ / 2-methoxy-ethanol / 40 h / 100 °C

With lithium hydroxide; potassium carbonate; trichlorophosphate; In tetrahydrofuran; chloroform; 2-methoxy-ethanol; N,N-dimethyl-formamide; 3.2: Vilsmeier acylation;
DOI:10.1021/jm051090r