2-tert-butyldimethylsiloxy-3-methoxymethoxy-5-(E)-(3-methoxymethoxy-1-propenyl)phenylethynyl 3-methoxy-4-methoxymethoxybenzene

Base Information

Chemical Name:2-tert-butyldimethylsiloxy-3-methoxymethoxy-5-(E)-(3-methoxymethoxy-1-propenyl)phenylethynyl 3-methoxy-4-methoxymethoxybenzene
CAS No.:263887-22-5
Molecular Formula:C₃₀H₄₂O₈Si
Molecular Weight:558.744
Hs Code.:

Synonyms:2-tert-butyldimethylsiloxy-3-methoxymethoxy-5-(E)-(3-methoxymethoxy-1-propenyl)phenylethynyl 3-methoxy-4-methoxymethoxybenzene

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Chemical Property of 2-tert-butyldimethylsiloxy-3-methoxymethoxy-5-(E)-(3-methoxymethoxy-1-propenyl)phenylethynyl 3-methoxy-4-methoxymethoxybenzene

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Technology Process of 2-tert-butyldimethylsiloxy-3-methoxymethoxy-5-(E)-(3-methoxymethoxy-1-propenyl)phenylethynyl 3-methoxy-4-methoxymethoxybenzene

There total 8 articles about 2-tert-butyldimethylsiloxy-3-methoxymethoxy-5-(E)-(3-methoxymethoxy-1-propenyl)phenylethynyl 3-methoxy-4-methoxymethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 263887-27-0
4-ethynyl-2-methoxy-1-(methoxymethoxy)benzene

: 263887-28-1
(E)-1-(4-tert-butyldimethylsiloxy-3-iodo-5-methoxymethoxyphenyl)-3-methoxymethoxy-1-propene

: 263887-22-5
2-tert-butyldimethylsiloxy-3-methoxymethoxy-5-(E)-(3-methoxymethoxy-1-propenyl)phenylethynyl 3-methoxy-4-methoxymethoxybenzene

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In toluene; at 20 ℃; for 22.5h;
DOI:10.3987/com-99-s63

Reference yield:

: 5533-00-6
3-methoxy-4-methoxymethoxy-benzaldehyde

: 263887-22-5
2-tert-butyldimethylsiloxy-3-methoxymethoxy-5-(E)-(3-methoxymethoxy-1-propenyl)phenylethynyl 3-methoxy-4-methoxymethoxybenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C / Heating; 3 h

2: 81 percent / Pd(PPh₃)4; CuI; Et₃N / toluene / 22.5 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; triethylamine; In tetrahydrofuran; hexane; toluene; 1: homologation / 2: Sonogashira cross coupling;
DOI:10.3987/com-99-s63

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 263887-22-5
2-tert-butyldimethylsiloxy-3-methoxymethoxy-5-(E)-(3-methoxymethoxy-1-propenyl)phenylethynyl 3-methoxy-4-methoxymethoxybenzene

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / i-Pr₂NEt / dimethylformamide / 13 h / 0 - 20 °C

2: 82 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C / Heating; 3 h

3: 81 percent / Pd(PPh₃)4; CuI; Et₃N / toluene / 22.5 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene; 1: Etherification / 2: homologation / 3: Sonogashira cross coupling;
DOI:10.3987/com-99-s63