tert-Butyl {5-[{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-thienyl}carbamate

Base Information

Chemical Name:tert-Butyl {5-[{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-thienyl}carbamate
CAS No.:1246246-74-1
Molecular Formula:C₅₀H₅₆F₇N₅O₇S
Molecular Weight:1004.08
Hs Code.:

tert-Butyl {5-[{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-thienyl}carbamate

Synonyms:tert-Butyl {5-[{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-thienyl}carbamate

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Chemical Property of tert-Butyl {5-[{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-thienyl}carbamate

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Technology Process of tert-Butyl {5-[{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-thienyl}carbamate

There total 17 articles about tert-Butyl {5-[{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-thienyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1094071-11-0
5-(N-tert-butoxycarbonyl)aminothiophene-2-carboxylic acid

: 1246246-70-7
2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide

: 1246246-74-1
tert-Butyl {5-[{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-thienyl}carbamate

Guidance literature:: 5-(N-tert-butoxycarbonyl)aminothiophene-2-carboxylic acid; With pivaloyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 0.25h; Cooling with ice;

2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide; In dichloromethane; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

: 1246246-61-6
2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethanol

: 1246246-74-1
tert-Butyl {5-[{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-thienyl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; triethylamine / dichloromethane / 1 h / Cooling with ice

2.1: sodium hydrogencarbonate / acetonitrile / 14 h / Inert atmosphere; Reflux

3.1: sodium hydroxide; water / methanol / 2 h / 20 °C / Cooling with ice

3.2: Cooling with ice

4.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / 20 °C / Cooling with ice

4.2: 1 h / 20 °C / Cooling with ice

5.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / 20 °C / Cooling with ice

5.2: 1 h / 20 °C / Cooling with ice

With dmap; water; pivaloyl chloride; sodium hydrogencarbonate; triethylamine; sodium hydroxide; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 1246246-58-1
(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-5-(4-fluorophenyl)-1,3-oxazolidine

: 1246246-74-1
tert-Butyl {5-[{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-thienyl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 2 h / 20 °C

2.1: dmap; triethylamine / dichloromethane / 1 h / Cooling with ice

3.1: sodium hydrogencarbonate / acetonitrile / 14 h / Inert atmosphere; Reflux

4.1: sodium hydroxide; water / methanol / 2 h / 20 °C / Cooling with ice

4.2: Cooling with ice

5.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / 20 °C / Cooling with ice

5.2: 1 h / 20 °C / Cooling with ice

6.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / 20 °C / Cooling with ice

6.2: 1 h / 20 °C / Cooling with ice

With dmap; tetrabutyl ammonium fluoride; water; pivaloyl chloride; sodium hydrogencarbonate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;