tert-butyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-2-(1-trityl-1H-imidazol-4-yl)hex-2-enoate

Base Information

Chemical Name:tert-butyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-2-(1-trityl-1H-imidazol-4-yl)hex-2-enoate
CAS No.:1334541-38-6
Molecular Formula:C₄₂H₅₁N₃O₆
Molecular Weight:693.883
Hs Code.:

Synonyms:tert-butyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-2-(1-trityl-1H-imidazol-4-yl)hex-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-2-(1-trityl-1H-imidazol-4-yl)hex-2-enoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-2-(1-trityl-1H-imidazol-4-yl)hex-2-enoate

There total 3 articles about tert-butyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-2-(1-trityl-1H-imidazol-4-yl)hex-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334541-36-4
tert-butyl (1-trityl-1H-imidazol-4-yl)acetate

: 177899-21-7
4-[N,N-bis(tert-butoxycarbonyl)amino]butyraldehyde

: 1334541-38-6
tert-butyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-2-(1-trityl-1H-imidazol-4-yl)hex-2-enoate

: 1334541-39-7
tert-butyl (2E)-6-[bis(tert-butoxycarbonyl)amino]-2-(1-trityl-1H-imidazol-4-yl)hex-2-enoate

Guidance literature:: tert-butyl (1-trityl-1H-imidazol-4-yl)acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.5h; Inert atmosphere;

4-[N,N-bis(tert-butoxycarbonyl)amino]butyraldehyde; In tetrahydrofuran; at -78 ℃; for 2.13333h; Further stages;

Reference yield:

: 64464-46-6
(1-trityl-1H-imidazol-4-yl)acetonitrile

: 1334541-38-6
tert-butyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-2-(1-trityl-1H-imidazol-4-yl)hex-2-enoate

: 1334541-39-7
tert-butyl (2E)-6-[bis(tert-butoxycarbonyl)amino]-2-(1-trityl-1H-imidazol-4-yl)hex-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol; water / 4 h / Reflux

2.1: boron trifluoride diethyl etherate / dichloromethane-d2 / 42 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

3.2: 2.13 h / -78 °C

With boron trifluoride diethyl etherate; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane-d2; water;

Reference yield:

: 168632-03-9
1-triphenylmethyl-4-imidazolyl-acetic acid

: 1334541-38-6
tert-butyl (2Z)-6-[bis(tert-butoxycarbonyl)amino]-2-(1-trityl-1H-imidazol-4-yl)hex-2-enoate

: 1334541-39-7
tert-butyl (2E)-6-[bis(tert-butoxycarbonyl)amino]-2-(1-trityl-1H-imidazol-4-yl)hex-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron trifluoride diethyl etherate / dichloromethane-d2 / 42 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

2.2: 2.13 h / -78 °C

With boron trifluoride diethyl etherate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane-d2;