1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[(1R,2R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropenyl-cyclohexyl]-5-(1,1-dimethyl-heptyl)-benzene

Base Information

• Chemical Name: 1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[(1R,2R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropenyl-cyclohexyl]-5-(1,1-dimethyl-heptyl)-benzene
• CAS No.: 213915-77-6
• Molecular Formula: C₄₃H₈₂O₃Si₃
• Molecular Weight: 731.379
• Mol file: 213915-77-6.mol

Synonyms:1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[(1R,2R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropenyl-cyclohexyl]-5-(1,1-dimethyl-heptyl)-benzene

Chemical Property of 1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[(1R,2R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropenyl-cyclohexyl]-5-(1,1-dimethyl-heptyl)-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[(1R,2R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropenyl-cyclohexyl]-5-(1,1-dimethyl-heptyl)-benzene

There total 7 articles about 1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[(1R,2R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropenyl-cyclohexyl]-5-(1,1-dimethyl-heptyl)-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyldimethylsilyl chloride (18162-48-6) + {(1R,3R,4R)-3-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-4-isopropenyl-cyclohexyl}-methanol (213915-76-5) → 1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[(1R,2R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropenyl-cyclohexyl]-5-(1,1-dimethyl-heptyl)-benzene (213915-77-6)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 17h; Ambient temperature;

DOI:10.1021/jm960677q

Reference yield:

(1R,4R,5R)-4-(2,6-dihydroxy-4-(2-methyloctan-2-yl)phenyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-one (182509-23-5) → 1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[(1R,2R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropenyl-cyclohexyl]-5-(1,1-dimethyl-heptyl)-benzene (213915-77-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 83 percent / imidazole, DMAP / dimethylformamide / 36 h / Ambient temperature

2: 1.) TMSI, t-BuOH, 2.) 1,8-diazabicyclo<5.4.0>undec-7-ene / 1.) CCl₄, 0 deg C, 1.5 h, 2.) C₆H₆, 50 deg C, 3 h

3: 1.) sodium tert-amylate / 1.) C₆H₆, RT, 15 min, 2.) C₆H₆, 70 deg C, 3 h

4: aq. CCl₃CO₂H / CH₂Cl₂ / 0.17 h / Ambient temperature

5: 72 percent / NaBH₄ / ethanol / 2 h / Ambient temperature

6: 100 percent / imidazole / dimethylformamide / 17 h / Ambient temperature

With 1H-imidazole; dmap; sodium tetrahydroborate; trimethylsilyl iodide; sodium tert-pentoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; tert-butyl alcohol; trichloroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm960677q

Reference yield:

(1R,4R,5R)-4-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-6,6-dimethyl-bicyclo[3.1.1]heptan-2-one (213915-73-2) → 1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[(1R,2R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropenyl-cyclohexyl]-5-(1,1-dimethyl-heptyl)-benzene (213915-77-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) TMSI, t-BuOH, 2.) 1,8-diazabicyclo<5.4.0>undec-7-ene / 1.) CCl₄, 0 deg C, 1.5 h, 2.) C₆H₆, 50 deg C, 3 h

2: 1.) sodium tert-amylate / 1.) C₆H₆, RT, 15 min, 2.) C₆H₆, 70 deg C, 3 h

3: aq. CCl₃CO₂H / CH₂Cl₂ / 0.17 h / Ambient temperature

4: 72 percent / NaBH₄ / ethanol / 2 h / Ambient temperature

5: 100 percent / imidazole / dimethylformamide / 17 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; trimethylsilyl iodide; sodium tert-pentoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; tert-butyl alcohol; trichloroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm960677q

upstream raw materials:

tert-butyldimethylsilyl chloride

{(1R,3R,4R)-3-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-4-isopropenyl-cyclohexyl}-methanol

(1R,4R,5R)-4-(2,6-dihydroxy-4-(2-methyloctan-2-yl)phenyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-one

(1R,4R,5R)-4-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-6,6-dimethyl-bicyclo[3.1.1]heptan-2-one

Downstream raw materials:

2-[(1R,2R,4R)-2-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohexyl]-prop-2-en-1-ol

2-{(1R,2R,4R)-2-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-4-hydroxymethyl-cyclohexyl}-prop-2-en-1-ol

2-[(1R,2R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2-(3-hydroxy-1-methylene-propyl)-cyclohexyl]-5-(1,1-dimethyl-heptyl)-benzene-1,3-diol

(6S,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-9-hydroxymethyl-6-(2-iodo-ethyl)-6-methyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-1-ol