[1-(5-methoxybenzimidazol)-2-ylmethylpiperidin-4-yl]-(4-⁽¹⁸⁾F-fluorophenyl)methanone

Base Information

• Chemical Name: [1-(5-methoxybenzimidazol)-2-ylmethylpiperidin-4-yl]-(4-⁽¹⁸⁾F-fluorophenyl)methanone
• CAS No.: 1310689-26-9
• Molecular Formula: C₂₁H₂₂FN₃O₂
• Molecular Weight: 366.425

Synonyms:[1-(5-methoxybenzimidazol)-2-ylmethylpiperidin-4-yl]-(4-⁽¹⁸⁾F-fluorophenyl)methanone

Chemical Property of [1-(5-methoxybenzimidazol)-2-ylmethylpiperidin-4-yl]-(4-⁽¹⁸⁾F-fluorophenyl)methanone

Chemical Property:

Purity/Quality:

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Technology Process of [1-(5-methoxybenzimidazol)-2-ylmethylpiperidin-4-yl]-(4-⁽¹⁸⁾F-fluorophenyl)methanone

There total 3 articles about [1-(5-methoxybenzimidazol)-2-ylmethylpiperidin-4-yl]-(4-⁽¹⁸⁾F-fluorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-yl]-(4-nitrophenyl)methanone (1310689-21-4) → [1-(5-methoxybenzimidazol)-2-ylmethylpiperidin-4-yl]-(4-(18)F-fluorophenyl)methanone (1310689-26-9)

Guidance literature:

With 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride; In dimethyl sulfoxide; at 140 ℃; for 0.25h; Sealed vial;

DOI:10.1016/j.ejmech.2011.03.013

Reference yield:

(4-nitrophenyl)(piperidin-4-yl)methanone (145851-04-3) → [1-(5-methoxybenzimidazol)-2-ylmethylpiperidin-4-yl]-(4-(18)F-fluorophenyl)methanone (1310689-26-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / acetonitrile / 72 h / 45 °C / Inert atmosphere

2: 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride / dimethyl sulfoxide / 0.25 h / 140 °C / Sealed vial

With 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride; sodium carbonate; In dimethyl sulfoxide; acetonitrile;

DOI:10.1016/j.ejmech.2011.03.013

Reference yield:

2-(chloromethyl)-5-methoxy-1H-benzimidazole (14625-40-2) → [1-(5-methoxybenzimidazol)-2-ylmethylpiperidin-4-yl]-(4-(18)F-fluorophenyl)methanone (1310689-26-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / acetonitrile / 72 h / 45 °C / Inert atmosphere

2: 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride / dimethyl sulfoxide / 0.25 h / 140 °C / Sealed vial

With 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride; sodium carbonate; In dimethyl sulfoxide; acetonitrile;

DOI:10.1016/j.ejmech.2011.03.013

upstream raw materials:

[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-yl]-(4-nitrophenyl)methanone

(4-nitrophenyl)(piperidin-4-yl)methanone

2-(chloromethyl)-5-methoxy-1H-benzimidazole

Downstream raw materials:

2-[4-(4-⁽¹⁸⁾F-fluorobenzyl)piperidin-1-yl]methyl-5-methoxybenzimidazole

2-[4-(4-⁽¹⁸⁾F-fluorobenzyl)piperidin-1-ylmethyl]benzimidazol-5-ol

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